INT140647

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2009
Negated 5
Speculated 1
Reported most in Body
Documents 45
Total Number 53
Disease Relevance 27.95
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DSG1) plasma membrane (DSG1)
Anatomy Link Frequency
basal layer 7
cleavage 6
skin 5
BxPC-3 3
keratinocytes 3
DSG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 135 96.92 Very High Very High Very High
Pain 47 82.40 Quite High
Kinase C 481 66.88 Quite High
diclofenac 2 50.00 Quite Low
Osteoarthritis 2 50.00 Quite Low
addiction 74 34.68 Quite Low
cva 2 13.60 Low Low
ischemia 1 8.84 Low Low
metalloproteinase 223 5.00 Very Low Very Low Very Low
agonist 185 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 11260 100.00 Very High Very High Very High
Dentinogenesis Imperfecta 172 100.00 Very High Very High Very High
Cleidocranial Dysplasia 114 100.00 Very High Very High Very High
Gastrointestinal Neoplasms 11 99.98 Very High Very High Very High
Acantholysis 2405 99.68 Very High Very High Very High
Skin Infection 148 99.48 Very High Very High Very High
Pancreatic Cancer 342 99.16 Very High Very High Very High
Autoimmune Disease 148 98.84 Very High Very High Very High
Disease 713 98.64 Very High Very High Very High
Blister 444 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the epidermis, Dsg1 is expressed throughout the upper differentiating cell layers, while Dsg3 is restricted to basal keratinocytes [41].
Gene_expression (expressed) of Dsg1 in keratinocytes
1) Confidence 0.75 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.79 Pain Relevance 0.05
Dsg1 was not detected in either of the cell lines (Fig. 4A, lanes 1 and 2), whereas Dsg2 was readily detected in BxPC-3 but not Panc-1 cell lysates (Fig. 4A, lanes 3 and 4, respectively).
Neg (not) Gene_expression (detected) of Dsg1 in BxPC-3
2) Confidence 0.75 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.24 Pain Relevance 0
IgG anti-desmoglein (Dsg)3 antibody, but not anti-Dsg1 antibody, was detected in the patient's serum by enzyme-linked immunosorbent assay.
Gene_expression (detected) of Dsg
3) Confidence 0.65 Published 2006 Journal J. Dermatol. Section Abstract Doc Link 17169086 Disease Relevance 0.57 Pain Relevance 0.08
The pancreatic cancer samples, however, showed an almost complete loss of cells displaying intense (3+) Dsg1 staining and a marked decrease in cells with 2+ intensity with a concomitant increase in cells with weak (1+) or absent (0+) Dsg1 staining.
Neg (absent) Gene_expression (staining) of Dsg1 associated with pancreatic cancer
4) Confidence 0.65 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.83 Pain Relevance 0.30
IgG anti-desmoglein (Dsg)3 antibody, but not anti-Dsg1 antibody, was detected in the patient's serum by enzyme-linked immunosorbent assay.
Gene_expression (detected) of Dsg1
5) Confidence 0.59 Published 2006 Journal J. Dermatol. Section Abstract Doc Link 17169086 Disease Relevance 0.57 Pain Relevance 0.08
To determine whether hK7 could participate in decreasing the levels of Dsg1 and Dsg2 through proteolytic cleavage, in vitro degradation assays were performed using recombinant hK7 and desmosomal proteins.
Gene_expression (levels) of Dsg1 in cleavage
6) Confidence 0.58 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.86 Pain Relevance 0.29
To identify pancreatic cancer cell lines that could be used to examine hK7-dependent cleavage of desmosomal proteins in a cell-based system, cell lysates were prepared from Panc-1 and BxPC-3 cell lines and assessed for the levels of Dsg1 and Dsg2 by western blot analysis.
Gene_expression (levels) of Dsg1 in BxPC-3 associated with pancreatic cancer
7) Confidence 0.58 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.24 Pain Relevance 0
In this report we have shown that the levels of cell-surface resident Dsg1 and Dsg2 are reduced in pancreatic adenocarcinomas compared with normal and chronic pancreatitis tissues.
Gene_expression (levels) of Dsg1 associated with adenocarcinoma and chronic pancreatitis
8) Confidence 0.58 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.51 Pain Relevance 0.10
The expression of Dsg1, Dsg2, and Dsg3 in pancreatic tissues was examined by immunohistochemistry and their expression in two pancreatic cancer cell lines, BxPC-3 and Panc-1, was determined by western blot analysis.
Spec (examined) Gene_expression (expression) of Dsg1 in BxPC-3 associated with pancreatic cancer
9) Confidence 0.58 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.48 Pain Relevance 0.06
The levels of immunoreactive Dsg1 and Dsg2 were reduced in pancreatic adenocarcinomas compared with both normal pancreatic and chronic pancreatitis tissues.
Gene_expression (levels) of Dsg1 associated with adenocarcinoma and chronic pancreatitis
10) Confidence 0.58 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.67 Pain Relevance 0.10
Consistent with previous findings [42], Dsg1 was detected throughout the epidermis from superficial to basal layers.
Gene_expression (detected) of Dsg1 in basal layers
11) Confidence 0.58 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.79 Pain Relevance 0.14
RESULTS: At week 12, the DSG group had significant decreases versus the vehicle group in mean WOMAC pain (P = 0.01), mean WOMAC physical function (P = 0.001), and mean global rating of disease (P < 0.001).
Gene_expression (group) of DSG
12) Confidence 0.58 Published 2009 Journal Semin. Arthritis Rheum. Section Body Doc Link 19932833 Disease Relevance 0.07 Pain Relevance 0
The only mutations causative of DGI and DD, with the exception of DD-I for which the underlying mutation(s) has been elucidated, are found in the dentine sialophosphoprotein gene (DSPP), suggesting that these conditions are indeed allelic (Table 1).
Neg (exception) Gene_expression (found) of DGI in dentine associated with cleidocranial dysplasia and dentinogenesis imperfecta
13) Confidence 0.52 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.56 Pain Relevance 0
Dentinogenesis imperfecta (DGI)
Gene_expression (imperfecta) of DGI associated with dentinogenesis imperfecta
14) Confidence 0.52 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 2.08 Pain Relevance 0
Similarly, forced suprabasal Dsg 2 and Dsc 3 overexpression resulted in hyperproliferation and formation of papillomas, possibly via altered ?
Gene_expression (overexpression) of Dsg associated with non-genital cutaneous warts
15) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.10 Pain Relevance 0.07
In multilayered squamous epithelium of mucous membranes, for instance of the oral cavity, Dsg 1 and Dsg 3 are strongly expressed throughout all layers, whereas Dsg 4 shows strong expression in superficial layers but is missing in the basal layer (Mahoney et al. 2006).
Gene_expression (expressed) of Dsg in basal layer
16) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.10 Pain Relevance 0
Apparently, exceptions are the additional presence of Dsg 1 in the mucosa of uterus, stomach, intestine and in epithelia of liver and pancreas as well as the expression of Dsc 1 in intestine and liver or Dsc 3 in stomach, prostate, salivary gland and urothelium.
Gene_expression (expression) of Dsg in stomach
17) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.15 Pain Relevance 0
More recently, Dsg 4 (108 kDa) was found to be the principal Dsg expressed in hair follicles (Kljuic et al. 2003; Whittock and Bower 2003).
Gene_expression (expressed) of Dsg in hair follicles
18) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.29 Pain Relevance 0
Based on the different autoantibody profiles in PV and PF together with the findings that Dsg 3 is present in the deep epidermis only whereas Dsg 1 is primarily expressed in the superficial epidermis, the desmoglein compensation hypothesis has been proposed to explain the epidermal cleavage planes typical for PV and PF.
Gene_expression (expressed) of Dsg in cleavage associated with bullous skin disease
19) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.09 Pain Relevance 0
However, acantholysis occurs in mucous membranes where Dsg 3 is assumed to be the predominantly expressed Dsg isoform, leading to the phenotype of mucosal-dominant PV.
Gene_expression (expressed) of Dsg associated with acantholysis and bullous skin disease
20) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.91 Pain Relevance 0

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