INT140650

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.43
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL11) extracellular space (CCL11) extracellular region (CCL11)
cell adhesion (CCL11) cytoskeleton organization (CCL11)
Anatomy Link Frequency
smooth muscle cells 4
upper 4
plasma 2
monocyte 2
lumen 2
CCL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 97 99.12 Very High Very High Very High
Inflammation 259 98.56 Very High Very High Very High
agonist 55 98.20 Very High Very High Very High
dexamethasone 61 96.08 Very High Very High Very High
cytokine 103 96.00 Very High Very High Very High
chemokine 82 95.36 Very High Very High Very High
metalloproteinase 6 95.16 Very High Very High Very High
corticosteroid 5 85.12 High High
Angina 3 65.44 Quite High
fibrosis 9 57.12 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 3 99.84 Very High Very High Very High
Rhinitis 46 99.82 Very High Very High Very High
Hypersensitivity 35 99.40 Very High Very High Very High
Fibromyalgia 97 99.12 Very High Very High Very High
INFLAMMATION 288 98.56 Very High Very High Very High
Asthma 396 97.00 Very High Very High Very High
Infection 9 94.40 High High
Chlamydia Infection 2 93.20 High High
Contact Dermatitis 28 89.64 High High
Disease 71 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apart from its functions in the eosinophilic system, eotaxin has been shown to be overexpressed in atherosclerosis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of eotaxin associated with rhinitis and increased venous pressure under development
1) Confidence 0.68 Published 2006 Journal J. Investig. Med. Section Abstract Doc Link 17169268 Disease Relevance 0.60 Pain Relevance 0.07
As shown in Figure 2, MCP-1, IP-10 and eotaxin plasma levels were elevated, on average, for all FMS patients vs. unrelated controls, except those with the rare alleles for the MEFV gene, who were empirically intermediate, but cannot be statistically distinguished from either controls or other FMS patients.
Positive_regulation (elevated) of Gene_expression (levels) of eotaxin in plasma associated with fibrositis
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.55 Pain Relevance 0.44
-induced production of eotaxin and monocyte chemotactic protein-1 by airway smooth muscle cells [67].
Positive_regulation (induced) of Gene_expression (production) of eotaxin in smooth muscle cells
3) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC2231357 Disease Relevance 0.55 Pain Relevance 0.30
-induced production of eotaxin and monocyte chemotactic protein-1 by airway smooth muscle cells [67].
Positive_regulation (-) of Gene_expression (production) of eotaxin in smooth muscle cells
4) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC2231357 Disease Relevance 0.55 Pain Relevance 0.30
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Positive_regulation (elevated) of Gene_expression (expression) of CCL11 in skin associated with inflammation
5) Confidence 0.23 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.74 Pain Relevance 0.22
Increased lumen levels of CCL11 have been associated with acute loss of mucosal eosinophils into the tracheal lumen in allergen-challenged guinea-pigs [115].
Positive_regulation (Increased) of Gene_expression (levels) of CCL11 in lumen
6) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2900258 Disease Relevance 0.10 Pain Relevance 0.09
Two recent reports demonstrated that human ASM cells expressed eotaxin mRNA and protein following TNF-?
Positive_regulation (following) of Gene_expression (expressed) of eotaxin
7) Confidence 0.18 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.47 Pain Relevance 0.39
Moreover, the GG genotype of Arg110Gln (110G>A) increased eotaxin-1 production, which might increase eosinophilic inflammation in the upper and lower airways of AIA patients.



Positive_regulation (increased) of Gene_expression (production) of eotaxin-1 in upper associated with asthma, rhinitis and inflammation
8) Confidence 0.08 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 0.74 Pain Relevance 0.09
Moreover, the GG genotype of Arg110Gln (110G>A) increased eotaxin-1 production, which might increase eosinophilic inflammation in the upper and lower airways of AIA patients.



Positive_regulation (increased) of Gene_expression (production) of eotaxin-1 in upper associated with asthma, rhinitis and inflammation
9) Confidence 0.06 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 0.74 Pain Relevance 0.09
Recently, increased expression of eotaxin and monocyte chemotactic protein-4 mRNA has been reported in the epithelial cell layer (Fig. 5) and in the airway wall of small airways of asthmatic persons as compared with nonasthmatic control individuals [6].
Positive_regulation (increased) of Gene_expression (expression) of eotaxin in monocyte associated with asthma
10) Confidence 0.04 Published 2001 Journal Respir Res Section Body Doc Link PMC64806 Disease Relevance 0.40 Pain Relevance 0.10

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