INT140653

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) extracellular space (IGF1)
Anatomy Link Frequency
cleavage 2
IGF1 (Homo sapiens)
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overdose 1 80.44 Quite High
Apoptosis 1 78.92 Quite High
Death 6 75.00 Quite High
Liver Failure 1 54.04 Quite High
Hepatotoxicity 1 52.52 Quite High
Hepatocellular Cancer 1 50.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with AAP treatment alone, IGF-I and AAP co-treatment increased ERK1/2 phosphorylation but inhibited PARP cleavage.
IGF-I Negative_regulation (inhibited) of Protein_catabolism (cleavage) of PARP in cleavage associated with paracetamol
1) Confidence 0.32 Published 2007 Journal Toxicology Section Abstract Doc Link 17169476 Disease Relevance 0.63 Pain Relevance 0.98

General Comments

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