INT140660

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) nucleoplasm (Phax) RNA binding (Phax)
plasma membrane (Trpv1) nucleus (Phax) lipid metabolic process (Trpv1)
Phax (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 5 100.00 Very High Very High Very High
dorsal root ganglion 25 99.20 Very High Very High Very High
qutenza 33 98.16 Very High Very High Very High
Inflammatory mediators 1 93.20 High High
Dopamine 1 90.16 High High
vagus nerve 1 88.24 High High
Dorsal horn 14 79.64 Quite High
trigeminal ganglion 1 78.32 Quite High
Intractable pain 2 60.00 Quite High
Spinal cord 23 56.92 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 27 99.20 Very High Very High Very High
Paralysis 1 93.20 High High
INFLAMMATION 18 92.80 High High
Intractable Pain 2 60.00 Quite High
Pain 10 26.96 Quite Low
Inflammatory Pain 1 23.76 Low Low
Bone Cancer 3 18.96 Low Low
Hypersensitivity 11 5.00 Very Low Very Low Very Low
Nociception 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined how sensitization and subsequent desensitization of the TRPV1 by resiniferatoxin (RTX), affected the responses of SARs to inhaled ammonia.
RTX Negative_regulation (desensitization) of TRPV1
1) Confidence 0.08 Published 2007 Journal Auton Neurosci Section Abstract Doc Link 17169618 Disease Relevance 0.19 Pain Relevance 0.09
We have previously demonstrated that RTX is a potent and irreversible agonist of TRPV1 [17].
RTX Negative_regulation (agonist) of TRPV1 associated with agonist
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.39 Pain Relevance 0.75

General Comments

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