INT140670

Context Info Confidence 0.51 First Reported 2006 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 4 Total Number 6 Disease Relevance 2.70 Pain Relevance 3.88

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)

Anatomy Link Frequency platelet 4 bowel 2 SLC6A4 (Homo sapiens)

Pain Link Frequency Relevance Heat Serotonin 55 100.00 5HT 6 99.64 fluoxetine 12 96.68 spastic colon 4 95.96 Pain 107 94.24 sSRI 11 90.64 Fibrositis 14 88.24 Hippocampus 1 81.76 agonist 7 81.28 Inflammation 1 81.04

Disease Link Frequency Relevance Heat Colitis 1 99.16 Inflammatory Bowel Disease 2 96.88 Functional Bowel Disorder 4 95.96 Appetite Loss 1 95.08 Pain 129 94.24 Anxiety Disorder 16 94.00 Fatigue 11 88.68 Neurosis 2 88.40 Fibromyalgia 10 88.24 Nociception 6 83.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The s-allele reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and availability [9].

Negative_regulation (decreased) of Gene_expression (expression) of 5-HTT

1) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2717925 Disease Relevance 0.75 Pain Relevance 0.91

The s-allele reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and availability [9].

Negative_regulation (decreased) of Gene_expression (expression) of 5-HTT

2) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2717925 Disease Relevance 0.80 Pain Relevance 0.97

In this study, we used cell cultures of platelet precursors as models of investigation on mechanisms of SERT regulation: SERT expression was appraised during megakaryocytic differentiation of human megakaryoblastic MEG-01 cells.

Negative_regulation (appraised) of Gene_expression (expression) of SERT in platelet

3) Confidence 0.43 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 20041293 Disease Relevance 0.34 Pain Relevance 0.18

Recent studies have shown that mucosal serotonin (5-HT) transporter (SERT) expression is decreased in animal models of colitis, as well as in the colonic mucosa of humans with ulcerative colitis and irritable bowel syndrome.

Negative_regulation (decreased) of Gene_expression (expression) of SERT in bowel associated with colitis, inflammatory bowel disease, spastic colon and serotonin

4) Confidence 0.41 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17170025 Disease Relevance 0.37 Pain Relevance 0.28

In the present study, both the expression and functionality of SERT were determined in platelets collected from patients with FM, with the following aims: first, to perform a comparison with the pharmacological profile of platelet SERT in healthy volunteers, and second, to examine putative correlations of SERT characteristics with the severity of symptoms such as tiredness, Fibromyalgia Impact Questionnaire (FIQ) score or tender point index (TPi).

Spec (determined) Negative_regulation (determined) of Gene_expression (expression) of SERT in platelet associated with fatigue and fibrositis

5) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779383 Disease Relevance 0.42 Pain Relevance 0.41

RT-PCR and immunostaining revealed the expression of serotonin transporter (SERT), 5HT(1A) receptors, tryptophan hydroxylase (TPH), and serotonin (5HT).

Negative_regulation (revealed) of Gene_expression (expression) of serotonin transporter associated with 5ht and serotonin

6) Confidence 0.06 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 1.13

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