INT140670

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 2.70
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
Anatomy Link Frequency
platelet 4
bowel 2
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 55 100.00 Very High Very High Very High
5HT 6 99.64 Very High Very High Very High
fluoxetine 12 96.68 Very High Very High Very High
spastic colon 4 95.96 Very High Very High Very High
Pain 107 94.24 High High
sSRI 11 90.64 High High
Fibrositis 14 88.24 High High
Hippocampus 1 81.76 Quite High
agonist 7 81.28 Quite High
Inflammation 1 81.04 Quite High
Disease Link Frequency Relevance Heat
Colitis 1 99.16 Very High Very High Very High
Inflammatory Bowel Disease 2 96.88 Very High Very High Very High
Functional Bowel Disorder 4 95.96 Very High Very High Very High
Appetite Loss 1 95.08 Very High Very High Very High
Pain 129 94.24 High High
Anxiety Disorder 16 94.00 High High
Fatigue 11 88.68 High High
Neurosis 2 88.40 High High
Fibromyalgia 10 88.24 High High
Nociception 6 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The s-allele reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and availability [9].
Negative_regulation (decreased) of Gene_expression (expression) of 5-HTT
1) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2717925 Disease Relevance 0.75 Pain Relevance 0.91
The s-allele reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and availability [9].
Negative_regulation (decreased) of Gene_expression (expression) of 5-HTT
2) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2717925 Disease Relevance 0.80 Pain Relevance 0.97
In this study, we used cell cultures of platelet precursors as models of investigation on mechanisms of SERT regulation: SERT expression was appraised during megakaryocytic differentiation of human megakaryoblastic MEG-01 cells.
Negative_regulation (appraised) of Gene_expression (expression) of SERT in platelet
3) Confidence 0.43 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 20041293 Disease Relevance 0.34 Pain Relevance 0.18
Recent studies have shown that mucosal serotonin (5-HT) transporter (SERT) expression is decreased in animal models of colitis, as well as in the colonic mucosa of humans with ulcerative colitis and irritable bowel syndrome.
Negative_regulation (decreased) of Gene_expression (expression) of SERT in bowel associated with colitis, inflammatory bowel disease, spastic colon and serotonin
4) Confidence 0.41 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17170025 Disease Relevance 0.37 Pain Relevance 0.28
In the present study, both the expression and functionality of SERT were determined in platelets collected from patients with FM, with the following aims: first, to perform a comparison with the pharmacological profile of platelet SERT in healthy volunteers, and second, to examine putative correlations of SERT characteristics with the severity of symptoms such as tiredness, Fibromyalgia Impact Questionnaire (FIQ) score or tender point index (TPi).


Spec (determined) Negative_regulation (determined) of Gene_expression (expression) of SERT in platelet associated with fatigue and fibrositis
5) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779383 Disease Relevance 0.42 Pain Relevance 0.41
RT-PCR and immunostaining revealed the expression of serotonin transporter (SERT), 5HT(1A) receptors, tryptophan hydroxylase (TPH), and serotonin (5HT).
Negative_regulation (revealed) of Gene_expression (expression) of serotonin transporter associated with 5ht and serotonin
6) Confidence 0.06 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 1.13

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