INT14068

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.30
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod)
cytoplasmic membrane-bounded vesicle (Umod) plasma membrane (Umod)
Anatomy Link Frequency
nerve cells 1
midbrain 1
Umod (Rattus norvegicus)
Pain Link Frequency Relevance Heat
midbrain 6 100.00 Very High Very High Very High
Spinal cord 12 99.92 Very High Very High Very High
Dorsal horn 8 99.76 Very High Very High Very High
Ventral tegmentum 7 99.70 Very High Very High Very High
fluoxetine 11 99.48 Very High Very High Very High
analgesia 1 98.68 Very High Very High Very High
Enkephalin 2 97.88 Very High Very High Very High
Lasting pain 2 95.84 Very High Very High Very High
Neuropathic pain 2 95.56 Very High Very High Very High
Sciatic nerve 3 94.32 High High
Disease Link Frequency Relevance Heat
Lordosis 8 100.00 Very High Very High Very High
Neuropathic Pain 7 99.48 Very High Very High Very High
Pain 8 95.84 Very High Very High Very High
Nervous System Injury 2 94.60 High High
Nociception 3 87.68 High High
Apoptosis 1 77.84 Quite High
Death 1 76.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administering fluoxetine to the VTA significantly increased lordosis and midbrain 3alpha,5alpha-THP levels compared to vehicle infusions.
Positive_regulation (increased) of THP in midbrain associated with ventral tegmentum, midbrain, lordosis and fluoxetine
1) Confidence 0.49 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 14993038 Disease Relevance 0.53 Pain Relevance 1.38
Enhancement of 3alpha,5alpha-THP concentration in the SC induced analgesia in neuropathic rats while Provera exacerbated their pathological state.
Positive_regulation (Enhancement) of THP associated with neuropathic pain, analgesia and spinal cord
2) Confidence 0.49 Published 2008 Journal Neurobiol. Dis. Section Abstract Doc Link 18291663 Disease Relevance 0.76 Pain Relevance 0.93
The upregulation of PREG and 3alpha/5alpha-THP biosynthesis might be involved in endogenous mechanisms triggered by neuropathic rats to cope with the chronic pain state. 3alpha/5alpha-THP formation from PREG can also generate PROG, which decreases sensitivity to pain and protects nerve cells against degeneration.
Positive_regulation (upregulation) of THP in nerve cells associated with pain, lasting pain and neuropathic pain
3) Confidence 0.45 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 16632873 Disease Relevance 1.01 Pain Relevance 0.96
After l-THP sc injection once daily for 2 wk, the striatal Leu-Enk level was elevated dose-dependently.
Positive_regulation (elevated) of l-THP
4) Confidence 0.10 Published 1991 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1685613 Disease Relevance 0 Pain Relevance 0.25

General Comments

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