INT140684

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.75
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ALCAM) cell adhesion (ALCAM)
Anatomy Link Frequency
leukocyte 3
stem cells 2
SH2 1
endothelial cells 1
hematopoietic stem cells 1
ALCAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 66.80 Quite High
tetrodotoxin 36 61.20 Quite High
imagery 6 40.08 Quite Low
addiction 3 13.68 Low Low
sodium channel 12 5.00 Very Low Very Low Very Low
potassium channel 12 5.00 Very Low Very Low Very Low
Calcium channel 9 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Osteoarthritis 8 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 6 100.00 Very High Very High Very High
Pancreatic Cancer 3 100.00 Very High Very High Very High
Cancer 8 99.84 Very High Very High Very High
Obesity 66 99.70 Very High Very High Very High
Aging 5 99.20 Very High Very High Very High
Classical Swine Fever 3 97.92 Very High Very High Very High
Lyme Disease 6 91.88 High High
Hemarthrosis 7 90.52 High High
Injury 4 69.52 Quite High
Pain 3 66.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flow cytometry analysis revealed that the adherent fibroblast-like cells were consistently positive for CD29, CD44, CD105, and CD166, and were negative for CD14, CD34, and CD45.
Gene_expression (positive) of CD166 in fibroblast
1) Confidence 0.45 Published 2007 Journal J. Cell. Physiol. Section Abstract Doc Link 17171634 Disease Relevance 0.62 Pain Relevance 0.07
The examined stem cell markers, CD44, CD73, CD166, CD105, CD90 and STRO1 showed stable expression level during the whole expansion period proving the results obtained by FACS analyses.
Gene_expression (expression) of CD166 in stem cell
2) Confidence 0.35 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.07 Pain Relevance 0
Vaisocherova et al devised an SPR assay for detection of the candidate pancreatic cancer marker activated cell leukocyte adhesion molecule (ALCAM) that can be used to distinguish between ALCAM levels in cancer and control sera [192].
Gene_expression (detection) of ALCAM in leukocyte associated with cancer, pancreatic cancer and adhesions
3) Confidence 0.29 Published 2009 Journal Respir Res Section Body Doc Link PMC2678087 Disease Relevance 0.69 Pain Relevance 0
Vaisocherova et al devised an SPR assay for detection of the candidate pancreatic cancer marker activated cell leukocyte adhesion molecule (ALCAM) that can be used to distinguish between ALCAM levels in cancer and control sera [192].
Gene_expression (detection) of leukocyte adhesion molecule in leukocyte associated with cancer, pancreatic cancer and adhesions
4) Confidence 0.29 Published 2009 Journal Respir Res Section Body Doc Link PMC2678087 Disease Relevance 0.69 Pain Relevance 0
Vaisocherova et al devised an SPR assay for detection of the candidate pancreatic cancer marker activated cell leukocyte adhesion molecule (ALCAM) that can be used to distinguish between ALCAM levels in cancer and control sera [192].
Gene_expression (levels) of ALCAM in leukocyte associated with cancer, pancreatic cancer and adhesions
5) Confidence 0.29 Published 2009 Journal Respir Res Section Body Doc Link PMC2678087 Disease Relevance 0.66 Pain Relevance 0
The hADSCs expressed MSC-specific cell type markers including CD13, CD44, CD90, and CD166, however, did not express CD14, CD34, and CD45 indicating that hADSCs in this study were of mesenchymal origin.
Gene_expression (expressed) of CD166
6) Confidence 0.28 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.31 Pain Relevance 0.05
As shown in Figure 1b, more than 95% of the adipose tissue-derived hMSCs expressed MSC-specific markers, including CD13, CD44 (endoglin), CD90 (Thy-1), and CD166, but did not express markers for hematopoietic stem cells, including CD14, CD34, and CD45.
Gene_expression (expressed) of CD166 in hematopoietic stem cells associated with obesity
7) Confidence 0.28 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.32 Pain Relevance 0.06
Adipose tissue-derived stem cells are understood to express surface markers of CD9, CD10, CD13, CD29, CD44, CD49d, CD49e, CD54, CD55, CD59, CD73, CD90, CD105, CD146, CD166, and STRO-1, and lack hematopoietic lineage markers CD11b, CD14, CD19, CD34, and CD45 [20,34,50-53].
Neg (lack) Gene_expression (express) of CD166 in stem cells associated with obesity
8) Confidence 0.28 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.23 Pain Relevance 0.06
Thus characterization by flow cytometry revealed that AM-hMSCs were positive for SH2 (anti-CD105), SH3 and SH4 (anti-CD73), CD29, CD44, CD166, and negative for the hematopoietic markers CD14, CD34, CD45 (Figure 4).


Neg (negative) Gene_expression (positive) of CD166 in SH2
9) Confidence 0.13 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0
These clones were negative for markers of hematopoetic stem cells (CD45) and endothelial cells (CD31) but positive (with variable expression) for MSC markers CD13, CD105, CD73, CD166, SSEA4, CD81, and CD90.
Neg (negative) Gene_expression (negative) of CD166 in endothelial cells
10) Confidence 0.05 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC3003945 Disease Relevance 0.16 Pain Relevance 0

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