INT140708

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.24
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr1) plasma membrane (Tlr1) intracellular (Tlr1)
Anatomy Link Frequency
T cells 2
monocytes 1
Tlr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 172 98.44 Very High Very High Very High
cytokine 210 97.92 Very High Very High Very High
tolerance 9 87.28 High High
agonist 9 74.80 Quite High
chemokine 17 67.16 Quite High
fibrosis 1 55.32 Quite High
Angina 5 50.00 Quite Low
Multiple sclerosis 12 6.60 Low Low
Central nervous system 36 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 297 99.66 Very High Very High Very High
Latent Tuberculosis 18 98.60 Very High Very High Very High
INFLAMMATION 178 98.44 Very High Very High Very High
Mycobacterial Infection 213 97.00 Very High Very High Very High
Schistosomiasis 3 93.20 High High
Francisella Infection 28 91.84 High High
Worm Infection 12 91.32 High High
Cancer 86 88.40 High High
Coronary Artery Disease 4 85.72 High High
Skin Cancer 8 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
T cells, express TLR1, TLR2 and dectin-1, respond to IL-23 and recognize various pathogens [42].
Gene_expression (express) of TLR1 in T cells
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.72 Pain Relevance 0
For example, freshly isolated human pDCs express TLR7 and 9, whereas mDCs express TLR1, 2, 3, 5, 6, and 8 [26-28].
Gene_expression (express) of TLR1
2) Confidence 0.40 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.11
For example, freshly isolated human pDCs express TLR7 and 9, whereas mDCs express TLR1, 2, 3, 5, 6, and 8 [26-28].
Gene_expression (express) of TLR1
3) Confidence 0.35 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.11
For instance, TLR1 was shown for the first time to be required, along with TLR2, for the activation of professional antigen-presenting cells by ?
Gene_expression (shown) of TLR1
4) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.39 Pain Relevance 0.12
B16 cells also expressed other members of the TLR family including TLR1, TLR3, TLR5, TLR6 and TLR7 (Figure S1C).
Gene_expression (expressed) of TLR1
5) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.96 Pain Relevance 0.13
The expression of Toll-like receptor 1, 2, and 4 on circulating CD14+ monocytes was analyzed by flow-cytometry in all patients.
Gene_expression (expression) of Toll-like receptor 1 in monocytes
6) Confidence 0.16 Published 2007 Journal Coron. Artery Dis. Section Body Doc Link 17172927 Disease Relevance 0.09 Pain Relevance 0
No significant correlation existed between the expression of Toll-like receptor 1 and the vessel score or Gensini score.
Gene_expression (expression) of Toll-like receptor 1
7) Confidence 0.16 Published 2007 Journal Coron. Artery Dis. Section Body Doc Link 17172927 Disease Relevance 0.07 Pain Relevance 0
By analyzing the baseline and mycobacterial antigen–stimulated expression of TLR1, 2, 4, and 9 (in individuals with latent tuberculosis [TB] with or without filarial infection), we were able to demonstrate that filarial infection, coincident with Mtb, significantly diminishes both baseline and Mtb antigen-specific TLR2 and TLR9 expression.
Gene_expression (expression) of TLR1 associated with mycobacterial infection, latent tuberculosis and infection
8) Confidence 0.09 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2710006 Disease Relevance 1.35 Pain Relevance 0.14
Similarly, individuals with filarial infection have diminished expression of APC- and T cell-specific-TLR1, 2, 4, and 9 as well as decreased pro-inflammatory cytokine responses to TLR2, 4, and 9 ligands [3],[4].
Gene_expression (expression) of TLR1 in T cell associated with inflammation, infection and cytokine
9) Confidence 0.09 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.96 Pain Relevance 0.10
To determine the impact of coexisting filarial infection on baseline and antigen-specific TLR expression of PPD+ individuals, and because filarial infection is associated with diminished expression of TLR1, 2, 4, and 9 [3], we examined the mRNA expression of these TLRs from PPD+Fil?
Gene_expression (expression) of TLR1 associated with infection
10) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.71 Pain Relevance 0

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