INT140710

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Cnga1) cytoplasm (Cnga1)
Anatomy Link Frequency
sensory neurons 2
Cnga1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 7 98.36 Very High Very High Very High
Pain 2 97.76 Very High Very High Very High
HCN1 7 94.64 High High
hCN2 7 93.92 High High
Neuronal excitability 1 93.92 High High
Trigeminal ganglion neurons 2 87.04 High High
Neuropathic pain 4 83.76 Quite High
Buprenorphine 2 75.00 Quite High
opioid receptor 2 25.84 Quite Low
agonist 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 98.36 Very High Very High Very High
Epilepsy 1 98.36 Very High Very High Very High
Pain 2 97.76 Very High Very High Very High
Nervous System Injury 1 97.24 Very High Very High Very High
Ganglion Cysts 2 86.16 High High
Neuropathic Pain 4 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alterations in HCN channel expression or function have been described in both epilepsy and cardiac arrhythmias.
Regulation (Alterations) of Gene_expression (expression) of HCN associated with epilepsy
1) Confidence 0.23 Published 2004 Journal Pain Pract Section Abstract Doc Link 17173600 Disease Relevance 0.39 Pain Relevance 0.29
The major aim of the current study was to investigate altered HCN channel protein expression in trigeminal sensory neurons following inflammation of the dura.
Spec (investigate) Regulation (altered) of Spec (investigate) Gene_expression (expression) of HCN in sensory neurons associated with inflammation
2) Confidence 0.17 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.53 Pain Relevance 0.63

General Comments

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