INT140720

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.43
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Reln) extracellular space (Reln) extracellular region (Reln)
cell adhesion (Reln) proteinaceous extracellular matrix (Reln) cytoplasm (Reln)
Anatomy Link Frequency
pyramidal neurons 1
MSN 1
Reln (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 20 99.66 Very High Very High Very High
Pyramidal cell 6 99.66 Very High Very High Very High
Opioid receptor 1 1 99.56 Very High Very High Very High
Glutamate receptor 1 98.76 Very High Very High Very High
GABAergic 1 97.48 Very High Very High Very High
Morphine 3 75.00 Quite High
analgesia 3 75.00 Quite High
midbrain 1 28.88 Quite Low
Pain 5 25.00 Low Low
Pain threshold 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Fibrosarcoma 2 98.04 Very High Very High Very High
Targeted Disruption 134 97.48 Very High Very High Very High
Autism 20 95.96 Very High Very High Very High
Stress 4 87.36 High High
Disease 1 85.40 High High
Anxiety Disorder 29 76.96 Quite High
Attention Deficit Hyperactivity Disorder 3 75.00 Quite High
Cancer 74 71.48 Quite High
Sarcoma 28 70.48 Quite High
Malignant Neoplastic Disease 10 68.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A downregulation of reelin may be a factor to be considered in the study of major psychiatric disorders.
Negative_regulation (downregulation) of reelin
1) Confidence 0.57 Published 2007 Journal Brain Res. Section Abstract Doc Link 17174287 Disease Relevance 0.37 Pain Relevance 0.34
Next to impaired serotonin signaling, also reduced reelin levels have been proposed to play an important role in several neurodevelopmental disorders such as autism (Fatemi, 2002).
Negative_regulation (reduced) of reelin associated with autism and serotonin
2) Confidence 0.57 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2987632 Disease Relevance 0.65 Pain Relevance 0.21
In the 5-HT3A knockout mouse an increase in dendritic complexity of the apical dendrites of cortical layer II/III pyramidal neurons together with a reduction in the glycoprotein reelin has been reported (Chameau et al., 2009).
Negative_regulation (reduction) of glycoprotein reelin in pyramidal neurons associated with targeted disruption and pyramidal cell
3) Confidence 0.05 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2987632 Disease Relevance 0.52 Pain Relevance 0.25
In the absence of Ctip2, MSN do not fully differentiate, as demonstrated by dramatically reduced expression of a large number of MSN markers, including DARPP-32, FOXP1, Chrm4, Reelin, MOR1 (mu-opioid receptor 1), glutamate receptor 1, and Plexin-D1.
Negative_regulation (number) of Reelin in MSN associated with glutamate receptor and opioid receptor 1
4) Confidence 0.04 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18199763 Disease Relevance 0.09 Pain Relevance 0.15
Unlike in HT1080 fibrosarcoma cells, we found that invasion of tumorigenic cen3tel cells was not reduced upon treatment with a matrix protease inhibitor, indicating that cells of mesenchymal origin can spontaneously undergo a transition towards amoeboid movement during transformation.
Negative_regulation (inhibitor) of matrix protease associated with fibrosarcoma
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.44 Pain Relevance 0
Experimental inhibition of pericellular proteolysis can induce a transition from mesenchymal to amoeboid movement [19]; in our cellular system, spontaneous downregulation of matrix protease genes, through a mechanism still to be clarified, might have contributed to the switch in the type of movement.
Negative_regulation (downregulation) of matrix protease
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.37 Pain Relevance 0

General Comments

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