INT140787

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.32
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3)
Anatomy Link Frequency
stomach 1
Ptger3 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 25 99.96 Very High Very High Very High
Inflammation 1 96.56 Very High Very High Very High
bradykinin 9 92.96 High High
b2 receptor 2 89.44 High High
nociceptor 2 82.32 Quite High
anesthesia 1 81.44 Quite High
COX2 2 25.00 Low Low
antagonist 2 25.00 Low Low
cINOD 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neurological Disease 2 97.56 Very High Very High Very High
INFLAMMATION 2 96.56 Very High Very High Very High
Bordatella Infection 1 74.48 Quite High
Stress 16 54.16 Quite High
Increased Venous Pressure Under Development 2 14.88 Low Low
Hypertension 1 5.00 Very Low Very Low Very Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Hypertrophy 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the roles of cyclooxygenase (COX) isozymes and prostaglandin E (PGE) receptor EP1 and EP3 subtypes or prostacyclin IP receptors in the decrease in acid secretion in the damaged mouse stomach.
Spec (investigated) Regulation (roles) of EP3 in stomach
1) Confidence 0.43 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17928639 Disease Relevance 0 Pain Relevance 0.08
The neuromodulatory effects of PGE(2) are mediated through regulation of four G-protein-coupled receptors known as EP1, EP2, EP3, and EP4.
Regulation (regulation) of EP3
2) Confidence 0.19 Published 2006 Journal J. Neurotrauma Section Abstract Doc Link 17184197 Disease Relevance 0.19 Pain Relevance 0.09
A protein kinase A inhibitor mimicked the effect of EP3 agonist.
Regulation (effect) of EP3 associated with agonist
3) Confidence 0.10 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17176262 Disease Relevance 0.07 Pain Relevance 0.76
Specifically, surface levels of neither EP3 nor EP4 were affected by exposure to H2O2, while by contrast levels of FP accessible to the surface probe were significantly and rapidly increased (Figure 10).
Regulation (affected) of EP3
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.05 Pain Relevance 0

General Comments

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