INT140795

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.16
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Smad3) intracellular (Smad3) DNA binding (Smad3)
protein complex (Smad3) cytoplasm (Smad3) nucleus (Smad3)
Anatomy Link Frequency
chondrocyte 4
MC3T3-E1 2
Smad3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 97.64 Very High Very High Very High
Osteoarthritis 273 84.00 Quite High
cytokine 15 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 36 99.92 Very High Very High Very High
Osteoporosis 4 99.84 Very High Very High Very High
Osteosclerosis 12 99.82 Very High Very High Very High
Pain 1 97.64 Very High Very High Very High
Alzheimer's Dementia 3 95.56 Very High Very High Very High
Osteoarthritis 288 84.00 Quite High
Aging 39 83.72 Quite High
Hepatitis 2 82.72 Quite High
Hyperostosis 1 80.88 Quite High
Syndrome 1 77.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of both Smad2 and Smad3 blocked spontaneous maturation in Smad3-deficient chondrocytes [70,71].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Smad3 in chondrocytes
1) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.19 Pain Relevance 0.03
The GST-Sox17 and GST-Smad3 fusion proteins (and GST only) were expressed in BL21 cells induced with 1 mM isopropyl ?
Positive_regulation (-) of Gene_expression (expressed) of Smad3
2) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.06 Pain Relevance 0
Overexpression of dominant negative Smad3 causes neurodegeneration in cell cultures, indicating that loss of Smad2/3 signaling is involved.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Smad3
3) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 1.06 Pain Relevance 0.17
on chondrocyte maturation is mediated by the Smad2/3 pathway, as has been shown by overexpression of dominant negative Smad2 and Smad3 in chondrocytes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Smad3 in chondrocyte
4) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.20 Pain Relevance 0
The serum from the HCAO patient increased the levels of TGF-beta and Smad3 expression in osteoblastic MC3T3-E1 cells, compared with the control subject.
Positive_regulation (increased) of Gene_expression (expression) of Smad3 in MC3T3-E1 associated with osteoporosis and osteosclerosis
5) Confidence 0.27 Published 2006 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 17177144 Disease Relevance 1.66 Pain Relevance 0.10

General Comments

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