INT140799

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.44
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn3) plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
nerve 4
DRG 4
Accn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 278 99.78 Very High Very High Very High
nociceptor 23 98.84 Very High Very High Very High
Inflammatory mediators 6 98.32 Very High Very High Very High
tissue acidosis 10 97.52 Very High Very High Very High
IPN 91 97.28 Very High Very High Very High
Nerve growth factor 8 96.92 Very High Very High Very High
Hyperalgesia 107 96.52 Very High Very High Very High
Pain 65 92.96 High High
vanilloid receptor subtype 1 3 91.48 High High
ASIC 28 88.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 285 99.78 Very High Very High Very High
Acidosis 24 97.52 Very High Very High Very High
Inflammatory Pain 91 97.28 Very High Very High Very High
Hyperalgesia 133 96.52 Very High Very High Very High
Pain 70 92.96 High High
Targeted Disruption 2 82.32 Quite High
Nociception 30 81.48 Quite High
Hematoma 1 76.16 Quite High
Cv Unclassified Under Development 2 75.72 Quite High
Infection 6 75.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that both AGM production [31,32] and ASIC3 expression [51,52] are increased during inflammation, the positive synergy between H+ and AGM in activating ASIC3 channels adds a new level of complexity to the molecular events that can lead to inflammatory pain.
Positive_regulation (increased) of Gene_expression (expression) of ASIC3 associated with inflammation and ipn
1) Confidence 0.68 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.19 Pain Relevance 1.02
Many studies have reported increased expression of acid-sensing ion channel 3 (ASIC3) in inflammation and enhanced ASIC3 channel activity with pro-inflammatory mediators.
Positive_regulation (increased) of Gene_expression (expression) of acid-sensing ion channel 3 associated with inflammatory mediators and inflammation
2) Confidence 0.47 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2632618 Disease Relevance 0.97 Pain Relevance 0.63
Enhanced expression of ASIC3 is probably due to promoter activation by stimulation of inflammatory mediators, especially nerve growth factor (NGF) [18-20].
Positive_regulation (Enhanced) of Gene_expression (expression) of ASIC3 in nerve associated with inflammatory mediators and nerve growth factor
3) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.98 Pain Relevance 1.00
In contrast to whole DRG, FISH of colonic neurons showed ASIC3 expression in 73 +/- 2%, ASIC2 in 47 +/- 0.5%, and ASIC1 in 30 +/- 2%.
Positive_regulation (showed) of Gene_expression (expression) of ASIC3 in DRG
4) Confidence 0.45 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.36
Enhanced expression of ASIC3 is probably due to promoter activation by stimulation of inflammatory mediators, especially nerve growth factor (NGF) [18-20].
Positive_regulation (due) of Gene_expression (expression) of ASIC3 in nerve associated with inflammatory mediators and nerve growth factor
5) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.03 Pain Relevance 1.00
With peripheral inflammation, the mRNA expression of TRPV1 and ASIC3 is increased in dorsal root ganglia (DRG) and sensitizes their responses [15-20].
Positive_regulation (increased) of Gene_expression (expression) of ASIC3 in DRG associated with inflammation
6) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.22 Pain Relevance 1.06

General Comments

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