INT140818

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 4.20
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
synovium 6
lymph nodes 2
T cells 2
Ifng (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.62 Very High Very High Very High
Arthritis 344 96.88 Very High Very High Very High
rheumatoid arthritis 216 93.04 High High
cytokine 136 90.44 High High
Inflammation 60 79.52 Quite High
Analgesic 2 65.04 Quite High
opiate 2 64.64 Quite High
cINOD 1 61.72 Quite High
Serotonin 1 36.32 Quite Low
chemokine 4 19.64 Low Low
Disease Link Frequency Relevance Heat
Immunization 1 99.98 Very High Very High Very High
Hepatotoxicity 4 99.92 Very High Very High Very High
Experimental Arthritis 28 97.24 Very High Very High Very High
Rheumatoid Arthritis 216 93.04 High High
Arthritis 276 88.92 High High
Injury 5 87.00 High High
INFLAMMATION 49 77.72 Quite High
Disease 121 72.64 Quite High
Apoptosis 1 68.20 Quite High
Juvenile Chronic Polyarthritis 20 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subacute and chronic administration of nefopam induced no significant raise in the level of interferon-gamma (IFN-gamma) or in the level of total immunoglobulins in non-immunized animals, while subacute and chronic treatment with nefopam augmented markedly the immunization induced increase of level of interferon-gamma (IFN-gamma).
Positive_regulation (induced) of Positive_regulation (increase) of IFN-gamma associated with immunization
1) Confidence 0.47 Published 2007 Journal Int. Immunopharmacol. Section Abstract Doc Link 17178394 Disease Relevance 0.16 Pain Relevance 0.31
Altogether, these results suggest that forced expression of SOCS3 in T cells is deleterious in APAP hepatotoxicity by increasing STAT1 activation while decreasing STAT3 activation in hepatocytes, possibly through elevated IFN-gamma and TNF-alpha.
Positive_regulation (increasing) of Spec (possibly) Positive_regulation (elevated) of IFN-gamma in T cells associated with paracetamol and hepatotoxicity
2) Confidence 0.30 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.64 Pain Relevance 0.27
In line with these findings, increased levels of IFN-gamma were detected in lymph nodes and synovium at later time points when adjuvant arthritis was induced in rats.
Positive_regulation (increased) of Positive_regulation (levels) of IFN-gamma in synovium associated with experimental arthritis and arthritis
3) Confidence 0.10 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.85 Pain Relevance 0.37
In line with these findings, increased levels of IFN-gamma were detected in lymph nodes and synovium at later time points when adjuvant arthritis was induced in rats.
Positive_regulation (levels) of Positive_regulation (increased) of IFN-gamma in synovium associated with experimental arthritis and arthritis
4) Confidence 0.10 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.85 Pain Relevance 0.37
In line with these findings, increased levels of IFN-gamma were detected in lymph nodes and synovium at later time points when adjuvant arthritis was induced in rats.
Positive_regulation (increased) of in lymph nodes Positive_regulation (levels) of IFN-gamma in synovium associated with experimental arthritis and arthritis
5) Confidence 0.04 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.85 Pain Relevance 0.37
In line with these findings, increased levels of IFN-gamma were detected in lymph nodes and synovium at later time points when adjuvant arthritis was induced in rats.
Positive_regulation (levels) of in lymph nodes Positive_regulation (increased) of IFN-gamma in synovium associated with experimental arthritis and arthritis
6) Confidence 0.04 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.85 Pain Relevance 0.37

General Comments

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