INT14085

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Context Info
Confidence 0.44
First Reported 1991
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cell 2
exocrine cells 1
Cd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 3 100.00 Very High Very High Very High
Arthritis 102 92.52 High High
Chronic pancreatitis 5 91.32 High High
opioid receptor 1 88.48 High High
fibrosis 1 70.64 Quite High
Inflammation 25 47.60 Quite Low
rheumatoid arthritis 27 28.96 Quite Low
narcan 1 25.00 Low Low
methotrexate 9 5.00 Very Low Very Low Very Low
Etanercept 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 102 92.52 High High
Toxicity 1 91.44 High High
Pancreatitis 5 91.32 High High
Apoptosis 6 88.32 High High
Pancreatic Cancer 1 85.84 High High
Stress 3 81.68 Quite High
Disease 36 75.52 Quite High
Fibrosis 1 70.64 Quite High
Autoimmune Disease 5 66.80 Quite High
INFLAMMATION 25 47.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phytol did not significantly alter T cell distribution, as no effect on the ratio of CD4/CD8 was seen (unpublished data).
Localization (ratio) of CD4 in T cell
1) Confidence 0.44 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 0.60 Pain Relevance 0.14
The pineal neurohormone melatonin was shown to stimulate the release of opioid peptides from activated CD4+, T lymphocytes.
Localization (release) of CD4 in T lymphocytes associated with opioid
2) Confidence 0.29 Published 1991 Journal Acta Neurol (Napoli) Section Abstract Doc Link 1685847 Disease Relevance 0.16 Pain Relevance 0.32
As a potential consequence, and possibly triggered by local release of IFNgamma, CD4-Th1 cells may cognately interact with and successfully attack exocrine cells by triggering CD95 on their target without being killed by epithelial, CD95L-mediated, counterattack.
Localization (release) of CD4 in exocrine cells
3) Confidence 0.04 Published 2001 Journal Lab. Invest. Section Abstract Doc Link 11310825 Disease Relevance 0.46 Pain Relevance 0.34

General Comments

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