INT140858

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.41
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SUGT1) mitosis (SUGT1)
Anatomy Link Frequency
plasma cell 1
cartilage 1
SUGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 94 98.40 Very High Very High Very High
tolerance 10 96.32 Very High Very High Very High
agonist 6 94.64 High High
Dopamine 7 88.20 High High
Catechol-O-methyltransferase 7 86.44 High High
Neurotransmitter 1 83.44 Quite High
Pain 32 79.68 Quite High
peptic ulcer disease 1 73.20 Quite High
Catecholamine 4 67.80 Quite High
Serotonin 8 49.28 Quite Low
Disease Link Frequency Relevance Heat
Multiple Hereditary Exostoses 90 99.80 Very High Very High Very High
Polycystic Ovary Syndrome 24 99.68 Very High Very High Very High
Cancer 28 99.24 Very High Very High Very High
Brain Injury 97 99.16 Very High Very High Very High
Sprains And Strains 4 99.04 Very High Very High Very High
Fibromyalgia 94 98.40 Very High Very High Very High
Osteochondroma 94 98.12 Very High Very High Very High
Diabetes Mellitus 90 98.08 Very High Very High Very High
Genetic Predisposition To Disease 2 96.64 Very High Very High Very High
Impaired Glucose Tolerance 10 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such a protective effect of Ala12 allele on insulin sensitivity can also be observed in human subjects carrying both the Ala12 allele and the Lys121Gln polymorphism of plasma cell 1 (PC-1) glycoprotein [112].
Negative_regulation (effect) of allele in plasma cell
1) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 0.28 Pain Relevance 0.04
Studies show that frequency of Ala12 allele is significantly reduced in the PCOS group compared with the control group [173, 174].
Negative_regulation (reduced) of allele associated with polycystic ovary syndrome
2) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.85 Pain Relevance 0.05
In a recent study, Buskila and colleagues [25] reported a significant decrease in the frequency of the 7 repeat allele in exon III of the D4 receptor gene in FMS patients who also demonstrated an association between this polymorphism and the low novelty seeking personality trait.
Negative_regulation (decrease) of allele associated with fibrositis
3) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779444 Disease Relevance 1.16 Pain Relevance 0.97
A simulation of allele frequencies over 50 generations have predicted haemoglobin S to diminish to a virtual complete loss of the allele by the 30th generation in Hausa, whereas in Massalit, the simulation predicts that the alleles will reach equilibrium by the fourth generation and be maintained while the selective pressure exits.
Negative_regulation (loss) of allele
4) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829010 Disease Relevance 0.93 Pain Relevance 0
If the parent is not MM, but is carrying a deficient allele next to the M allele (i.e.
Negative_regulation (deficient) of allele
5) Confidence 0.01 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.73 Pain Relevance 0
Research utilizing fMRI revealed differences in activation patterns during a working memory task depending on the presence or absence of the val allele in both control and TBI subjects, with additional differences in activation patterns resulting from administration of a dopaminergic agonist (McAllister et al 2004).
Negative_regulation (absence) of allele associated with agonist and brain injury
6) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626927 Disease Relevance 0.61 Pain Relevance 0.26
Loss of the remaining EXT1 wildtype allele has been demonstrated in the cartilage cap of osteochondromas from MO patients [39].
Negative_regulation (Loss) of allele in cartilage associated with osteochondroma and multiple hereditary exostoses
7) Confidence 0.00 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2276198 Disease Relevance 0.86 Pain Relevance 0
However, in a considerable proportion of MO patients loss of the remaining wildtype allele could not be detected so far [43].
Negative_regulation (loss) of allele associated with multiple hereditary exostoses
8) Confidence 0.00 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2276198 Disease Relevance 0.84 Pain Relevance 0
The great majority (92.6%) of the strains were typed as iceA1, while 40.4% were found to possess the babA2 allele.
Negative_regulation (possess) of babA2 allele associated with sprains and strains
9) Confidence 0.00 Published 2006 Journal Acta Trop. Section Abstract Doc Link 17181989 Disease Relevance 1.16 Pain Relevance 0.07

General Comments

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