INT14086

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Context Info
Confidence 0.34
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 4.32
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINB1) cytoplasm (SERPINB1)
Anatomy Link Frequency
thymus 2
liver 1
platelets 1
synapse 1
SERPINB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 12 100.00 Very High Very High Very High
opioid receptor 2 99.84 Very High Very High Very High
Opioid 6 99.58 Very High Very High Very High
substance P 8 93.48 High High
chest pain 3 91.84 High High
corticosteroid 1 90.64 High High
anesthesia 3 85.20 High High
Dorsal horn 1 83.56 Quite High
Action potential 3 80.32 Quite High
Central nervous system 11 77.40 Quite High
Disease Link Frequency Relevance Heat
Prostate Cancer 2 99.34 Very High Very High Very High
Stroke 10 96.54 Very High Very High Very High
Stress 14 96.44 Very High Very High Very High
Anaerobic Bacterial Infections 1 94.16 High High
Diphtheria 1 93.68 High High
Chest Pain 3 91.84 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 91.68 High High
Synovitis 2 90.84 High High
Pressure And Volume Under Development 4 89.88 High High
Anti-phospholipid Antibody Syndrome 5 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fenbufen itself was devoid of this anti-PG-synthetase activity although it interacted with prostaglandins in other ways.
anti-PG-synthetase Binding (interacted) of
1) Confidence 0.34 Published 1980 Journal Arzneimittelforschung Section Abstract Doc Link 7002162 Disease Relevance 0.78 Pain Relevance 0.19
Photobleaching fluorescence resonance energy transfer (pFRET) measurements on flow-sorted cells suggests that these two antibodies compete for the same epitope, while anti-LAM1-5-FITC and anti-Leu8-PE bind to distinct sites, although they also compete for binding.
anti-LAM1-5 Binding (bind) of
2) Confidence 0.06 Published 1993 Journal Mol. Immunol. Section Abstract Doc Link 7505884 Disease Relevance 0.08 Pain Relevance 0.08
Since EI(A B) is necessarily bounded by the maximum entropy available to A or B, min{EI(A B)}, to be comparable over bipartitions, should be normalized by Hmax(A B) = min{Hmax(A); Hmax(B)}, the maximum information capacity for each bipartition.
EI Binding (bounded) of
3) Confidence 0.05 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
The minimum information bipartition MIBA B of subset S – its 'weakest link' – is its bipartition for which the normalized effective information reaches a minimum, corresponding to min{EI(A B)/Hmax(A B)}.
EI Binding (min) of
4) Confidence 0.05 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
Two other anti-LAM1 antibodies, anti-LAM1-3 and anti-LAM1-5 stay antigen-bound at the same time.
anti-LAM1-5 Binding (antigen-bound) of
5) Confidence 0.05 Published 1993 Journal Mol. Immunol. Section Abstract Doc Link 7505884 Disease Relevance 0.09 Pain Relevance 0
While strokes secondary to SCAD are reported [10,11], albeit extremely rarely and in younger subjects, they have not been reported, to the best of our knowledge, in a middle-aged man in association with anti-cardiolipin antibodies.
anti-cardiolipin Binding (association) of associated with stroke
6) Confidence 0.02 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2848682 Disease Relevance 1.06 Pain Relevance 0.12
All subjects were seropositive for anti-FHA and anti-PRN but 4% of the initially seronegatives in both reduced aluminium groups did not seroconvert for anti-PT.
anti-PT Neg (not) Binding (seroconvert) of
7) Confidence 0.01 Published 2005 Journal Vaccine Section Abstract Doc Link 15670888 Disease Relevance 0.32 Pain Relevance 0.13
These immuno-derived opioids or "lymphomorphins" crossreact with anti-beta-endorphin and anti-metenkephalin antisera, bind to opioid receptors in the thymus and are the mediators of the immunoenhancing and anti-stress action of endogenous and/or exogenous melatonin.
anti-metenkephalin antisera Binding (crossreact) of in thymus associated with stress, opioid receptor and opioid
8) Confidence 0.01 Published 1991 Journal Acta Neurol (Napoli) Section Abstract Doc Link 1685847 Disease Relevance 0.17 Pain Relevance 0.32
We conclude that anti-Id Ab recognize NK-P receptors, although crossreaction with NK-A or NK-B receptors cannot be totally ruled out.
anti-Id Ab Binding (recognize) of
9) Confidence 0.01 Published 1988 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2844889 Disease Relevance 0.08 Pain Relevance 0.49
These immuno-derived opioids or "lymphomorphins" crossreact with anti-beta-endorphin and anti-metenkephalin antisera, bind to opioid receptors in the thymus and are the mediators of the immunoenhancing and anti-stress action of endogenous and/or exogenous melatonin.
anti-metenkephalin antisera Binding (bind) of in thymus associated with stress, opioid receptor and opioid
10) Confidence 0.01 Published 1991 Journal Acta Neurol (Napoli) Section Abstract Doc Link 1685847 Disease Relevance 0.17 Pain Relevance 0.32
In spite of this, attempts have been made to record the association of certain antibodies, e.g., anti-ribosomal P, anti-NMDAR, anti-phospholipids, with NPSLE, since the former usually accompany the latter.
anti-ribosomal P Binding (association) of
11) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556096 Disease Relevance 0.74 Pain Relevance 0.12
Treatment of advanced prostatic cancer with anti-androgens alone and a combination of anti-androgen with anti-prolactin--a pilot study.
anti-androgen Binding (combination) of associated with prostate cancer
12) Confidence 0.00 Published 1986 Journal Urol. Res. Section Title Doc Link 2944268 Disease Relevance 0.20 Pain Relevance 0.08
These anticholinesterase (anti-ChE) agents interacted with pre- and post-synaptic regions of the glutamatergic neuromuscular synapse.
anti-ChE Binding (interacted) of in synapse
13) Confidence 0.00 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2876093 Disease Relevance 0 Pain Relevance 0.11
Other cells react with anti-hGH, anti-bLH, anti-beta aLH or anti-beta hTSH antibodies.
anti-beta aLH Binding (react) of
14) Confidence 0.00 Published 1982 Journal Cell Tissue Res. Section Abstract Doc Link 6293724 Disease Relevance 0 Pain Relevance 0.15
Anti-r/hCRH or anti-hACTH treatment was not associated with a change in survival rate.
anti-hACTH Binding (associated) of
15) Confidence 0.00 Published 1988 Journal Endocrinology Section Abstract Doc Link 2826112 Disease Relevance 0.26 Pain Relevance 0.09
Positive staining with both the anti-APAP and the anti-P4502E1 antibodies was similar in distribution, being present in the cell types which become damaged by APAP in all four target tissues.
anti-APAP Binding (staining) of associated with paracetamol
16) Confidence 0.00 Published 1995 Journal Fundam Appl Toxicol Section Abstract Doc Link 7737437 Disease Relevance 0.37 Pain Relevance 0.87
Platelet activation markers for ex vivo analysis may include a) activation-dependent epitopes of the membrane glycoprotein (GP) IIb/IIIa (CD41a) receptor, as demonstrated by the binding of activation-specific monoclonal antibodies (MoAbs) PAC1, anti-LIBS1 and anti-RIBS); b) the expression of P-selectin (CD62p), the alpha-granule GP translocated to the platelet surface following release reaction; and c) platelet procoagulant activity, as demonstrated by the binding of i) annexin V protein to the prothrombinase-complex (prothrombin, activated factor X (Xa) and V (Va)) binding sites on the surface of activated platelets, and of ii) MoAbs against activated coagulation factors V and X bound to the surface of activated platelets.
anti-LIBS1 Binding (binding) of in platelets
17) Confidence 0.00 Published 2004 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 15471223 Disease Relevance 0 Pain Relevance 0
Ferret liver microsomes also contain a protein recognized by rat anti-P4502E1 but of a lower molecular weight. 5.
anti-P4502E1 Binding (recognized) of in liver
18) Confidence 0.00 Published 1994 Journal Xenobiotica Section Abstract Doc Link 7701848 Disease Relevance 0 Pain Relevance 0.06

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