INT140874

Context Info Confidence 0.36 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 0.85 Pain Relevance 0.69

nucleus (MNX1)

Anatomy Link Frequency medial 1 motoneuron 1 MNX1 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 33 99.24 headache 2 98.82 gABA 8 96.64 metalloproteinase 41 96.16 Dopamine 9 88.48 midbrain 5 80.80 Central nervous system 7 55.24 Pain 34 50.00 Spinal cord 7 21.20 Glutamate 7 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 35 99.68 Disease 8 99.16 Headache 1 98.80 Congenital Anomalies 1 93.76 Rheumatoid Arthritis 38 89.84 Osteophyte 7 87.92 Hyperglycemia 1 82.96 Pain 33 50.00 Arrhythmias 2 Under Development 1 22.56 Apoptosis 2 9.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Adult index patient with Currarino syndrome due to a novel HLXB9 mutation, c.336dupG (p.P113fsX224), presenting with Hirschsprung's disease, cephalgia, and lumbodynia.

HLXB9 Binding (presenting) of associated with headache, disease and osteoarthritis

1) Confidence 0.36 Published 2007 Journal Birth Defects Res. Part A Clin. Mol. Teratol. Section Title Doc Link 17183586 Disease Relevance 0.49 Pain Relevance 0.20

ngn3, Pdx1, and Hb9 are essential factors for mammalian ?

Hb9 Binding (factors) of

2) Confidence 0.23 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.17 Pain Relevance 0

5), but negative for motoneuron progenitors (HB9?

HB9 Binding (negative) of in motoneuron

3) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.29

MNX was associated with the expected OA changes in the medial tibial plateaux at day 35.

MNX Binding (associated) of in medial associated with osteoarthritis

4) Confidence 0.04 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2853084 Disease Relevance 0.19 Pain Relevance 0.21

General Comments

This test has worked.