INT140874

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.85
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MNX1)
Anatomy Link Frequency
medial 1
motoneuron 1
MNX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 33 99.24 Very High Very High Very High
headache 2 98.82 Very High Very High Very High
gABA 8 96.64 Very High Very High Very High
metalloproteinase 41 96.16 Very High Very High Very High
Dopamine 9 88.48 High High
midbrain 5 80.80 Quite High
Central nervous system 7 55.24 Quite High
Pain 34 50.00 Quite Low
Spinal cord 7 21.20 Low Low
Glutamate 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 35 99.68 Very High Very High Very High
Disease 8 99.16 Very High Very High Very High
Headache 1 98.80 Very High Very High Very High
Congenital Anomalies 1 93.76 High High
Rheumatoid Arthritis 38 89.84 High High
Osteophyte 7 87.92 High High
Hyperglycemia 1 82.96 Quite High
Pain 33 50.00 Quite Low
Arrhythmias 2 Under Development 1 22.56 Low Low
Apoptosis 2 9.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adult index patient with Currarino syndrome due to a novel HLXB9 mutation, c.336dupG (p.P113fsX224), presenting with Hirschsprung's disease, cephalgia, and lumbodynia.
HLXB9 Binding (presenting) of associated with headache, disease and osteoarthritis
1) Confidence 0.36 Published 2007 Journal Birth Defects Res. Part A Clin. Mol. Teratol. Section Title Doc Link 17183586 Disease Relevance 0.49 Pain Relevance 0.20
ngn3, Pdx1, and Hb9 are essential factors for mammalian ?
Hb9 Binding (factors) of
2) Confidence 0.23 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.17 Pain Relevance 0
5), but negative for motoneuron progenitors (HB9?
HB9 Binding (negative) of in motoneuron
3) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.29
MNX was associated with the expected OA changes in the medial tibial plateaux at day 35.
MNX Binding (associated) of in medial associated with osteoarthritis
4) Confidence 0.04 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2853084 Disease Relevance 0.19 Pain Relevance 0.21

General Comments

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