INT140896

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.38
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (GPNMB) cytoplasmic membrane-bounded vesicle (GPNMB)
Anatomy Link Frequency
astrocytes 3
endothelial cells 2
retina 1
endothelium 1
lamina 1
GPNMB (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 1 93.96 High High
Spontaneous pain 2 92.00 High High
Inflammation 19 90.28 High High
Inflammatory stimuli 1 88.00 High High
COX2 2 25.00 Low Low
anesthesia 35 5.00 Very Low Very Low Very Low
Central nervous system 28 5.00 Very Low Very Low Very Low
ketamine 28 5.00 Very Low Very Low Very Low
Kinase C 15 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 637 100.00 Very High Very High Very High
Ganglion Cysts 161 99.36 Very High Very High Very High
Adhesions 2 98.68 Very High Very High Very High
Sprains And Strains 15 97.96 Very High Very High Very High
Disease 54 96.64 Very High Very High Very High
Syndrome 15 96.08 Very High Very High Very High
Frailty 14 95.04 Very High Very High Very High
Psoriasis 1 93.96 High High
Inflammatory Bowel Disease 7 93.48 High High
Asthma 6 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
qRT-PCR was used to examine the expression of GPNMB, RBP1, CAPG, APOE, TGFBI, and TIMP1, which were identified in the nonhuman primate model, in immuno-enriched optic nerve head astrocytes from glaucomatous Caucasian American donors [see Additional file 7 and Additional file 8].
Spec (examine) Gene_expression (expression) of GPNMB in astrocytes
1) Confidence 0.51 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.54 Pain Relevance 0
Within the optic nerve head, healthy samples had baseline expression levels of GPNMB protein in astrocytes and retinal ganglion cell axons (Figure 3C).
Gene_expression (expression) of GPNMB protein in astrocytes associated with ganglion cysts
2) Confidence 0.40 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.95 Pain Relevance 0
GPNMB was chosen because it is a null mutation in the DBA/2J mouse strain, which develops iris pigment dispersion syndrome and iris stromal atrophy; the former was mapped to a premature stop mutation in GPNMB [64,65]; NEFH and GAP43 were chosen because they are markers of axonal regrowth [66,67], which has not been previously described in a primate glaucoma model.
Gene_expression (chosen) of GPNMB in iris associated with syndrome, frailty, glaucoma and sprains and strains
3) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.49 Pain Relevance 0
In control samples, GPNMB protein was detected in the retinal ganglion cell and nerve fiber layers of the retina (Figure 3A).
Gene_expression (detected) of GPNMB protein in retina associated with ganglion cysts
4) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.93 Pain Relevance 0
Abundant GPNMB was also present in axons in the nerve bundles at the level of the lamina cribrosa (Figure 3D).
Gene_expression (present) of GPNMB in lamina
5) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.95 Pain Relevance 0
Differential expression of motility genes, including capping protein G (CAPG) and transforming growth factor beta-induced (TGFBI), was consistent with the reactive, migratory astrocyte phenotype characteristic of glaucoma [12], as were ECM remodeling genes, such as GPNMB [79,80] and TIMP1 [81,82].
Gene_expression (expression) of GPNMB in astrocyte associated with glaucoma
6) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.46 Pain Relevance 0
Within the optic nerve head, healthy samples had baseline expression levels of GPNMB protein in astrocytes and retinal ganglion cell axons (Figure 3C).
Gene_expression (expression) of GPNMB protein in retinal ganglion cell associated with ganglion cysts
7) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.95 Pain Relevance 0
This study was undertaken to investigate the immunohistological co-expression of COX-2 and VEGF in inflamed human pulp, in conjunction with the expression of CD34, a transmembrane glycoprotein expressed in endothelial cells.
Gene_expression (expression) of transmembrane glycoprotein in endothelial cells
8) Confidence 0.05 Published 2007 Journal J Endod Section Abstract Doc Link 17185121 Disease Relevance 0.09 Pain Relevance 0.09
This study was undertaken to investigate the immunohistological co-expression of COX-2 and VEGF in inflamed human pulp, in conjunction with the expression of CD34, a transmembrane glycoprotein expressed in endothelial cells.
Gene_expression (expressed) of transmembrane glycoprotein in endothelial cells
9) Confidence 0.05 Published 2007 Journal J Endod Section Abstract Doc Link 17185121 Disease Relevance 0.09 Pain Relevance 0.09
ICAM-1 is a transmembrane glycoprotein that is constitutively expressed at low levels by vascular and colonic endothelium and a subset of leucocytes [125].
Gene_expression (expressed) of transmembrane glycoprotein in endothelium
10) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 1.91 Pain Relevance 0.22

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