INT140906

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 5.28
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
monocytes 2
Il12a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 34 100.00 Very High Very High Very High
cytokine 24 100.00 Very High Very High Very High
Multiple sclerosis 2 97.00 Very High Very High Very High
Crohn's disease 12 96.76 Very High Very High Very High
Central nervous system 6 95.00 High High
headache 2 88.96 High High
aspirin 26 83.04 Quite High
rheumatoid arthritis 7 69.84 Quite High
Serotonin 32 66.32 Quite High
Glutamate 2 64.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 48 100.00 Very High Very High Very High
Disease 21 99.74 Very High Very High Very High
Autoimmune Disease 6 98.64 Very High Very High Very High
Multiple Sclerosis 6 97.00 Very High Very High Very High
Demyelinating Disease 2 95.88 Very High Very High Very High
Schizophrenia 36 95.60 Very High Very High Very High
Headache 2 88.96 High High
Vomiting 2 87.84 High High
Periodontal Disease 66 84.36 Quite High
Necrosis 5 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apilimod is a small molecule that inhibits IL-12 and IL-23 production - cytokines that are involved in autoimmune diseases - through the prevention of nuclear translocation of c-Rel.
Negative_regulation (inhibits) of Gene_expression (production) of IL-12 associated with autoimmune disease and cytokine
1) Confidence 0.38 Published 2007 Journal IDrugs Section Abstract Doc Link 17187316 Disease Relevance 0.68 Pain Relevance 0.25
Preclinical studies demonstrated the successful inhibition of IL-12 and IL-23 production by the drug.
Negative_regulation (inhibition) of Gene_expression (production) of IL-12
2) Confidence 0.27 Published 2007 Journal IDrugs Section Abstract Doc Link 17187316 Disease Relevance 1.07 Pain Relevance 0.41
Venlafaxine ameliorated the clinical symptoms of the disease possibly by suppressed production of pro-inflammatory cytokines interleukin-12 (IL-12), p40, TNF-?
Negative_regulation (suppressed) of Gene_expression (production) of interleukin-12 associated with inflammation, disease and cytokine
3) Confidence 0.19 Published 2010 Journal J Negat Results Biomed Section Body Doc Link PMC2895576 Disease Relevance 1.31 Pain Relevance 0.35
Venlafaxine ameliorated the clinical symptoms of the disease possibly by suppressed production of pro-inflammatory cytokines interleukin-12 (IL-12), p40, TNF-?
Negative_regulation (suppressed) of Gene_expression (production) of IL-12 associated with inflammation, disease and cytokine
4) Confidence 0.19 Published 2010 Journal J Negat Results Biomed Section Body Doc Link PMC2895576 Disease Relevance 1.31 Pain Relevance 0.35
Prostaglandin E2 is known to enhance the production of TH2 cytokines via inhibition of the production of IL-12 by antigen presenting cells such as monocytes [13].
Negative_regulation (inhibition) of Gene_expression (production) of IL-12 in monocytes associated with cytokine
5) Confidence 0.11 Published 2006 Journal Trials Section Body Doc Link PMC1626076 Disease Relevance 0.91 Pain Relevance 0.50

General Comments

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