INT140929

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Context Info
Confidence 0.72
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 8.76
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40) molecular_function (Cd40)
Anatomy Link Frequency
platelet 2
plasma 1
notch 1
lymph nodes 1
bowel 1
Cd40 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 10 100.00 Very High Very High Very High
Neuritis 36 99.84 Very High Very High Very High
Sciatic nerve 3 99.60 Very High Very High Very High
Inflammation 184 98.00 Very High Very High Very High
tolerance 4 85.84 High High
fibrosis 19 82.48 Quite High
nud 20 80.72 Quite High
spastic colon 28 57.64 Quite High
Inflammatory mediators 1 55.04 Quite High
agonist 4 46.16 Quite Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 36 99.84 Very High Very High Very High
Heart Arrhythmia 861 99.58 Very High Very High Very High
Disease 38 99.20 Very High Very High Very High
Adhesions 15 99.16 Very High Very High Very High
Immunization 6 98.82 Very High Very High Very High
Mucositis 4 98.32 Very High Very High Very High
Death 25 96.48 Very High Very High Very High
Inflammatory Bowel Disease 4 95.68 Very High Very High Very High
Diabetes Mellitus 26 94.72 High High
Autoimmune Disease 13 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, both CD40 and CD40L expressing cells in sciatic nerves, a target organ of EAN, peaked on day 14 p.i., large numbers of both expressing cells were mainly detected on day 14-21 p.i.
Gene_expression (expressing) of CD40 in sciatic nerves associated with sciatic nerve and neuritis
1) Confidence 0.72 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 1.01 Pain Relevance 0.78
In draining lymph nodes, highest level of CD40L expression was seen on day 7 post immunization (p.i.), i.e. before onset of clinical signs of EAN, while CD40 expression was increased on day 14 p.i., i.e. at peak of clinical disease.
Gene_expression (expression) of CD40 in lymph nodes associated with immunization, disease and neuritis
2) Confidence 0.72 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 0.98 Pain Relevance 0.74
The expression of co-stimulatory molecules CD40 and CD40L was examined over the course of experimental autoimmune neuritis (EAN) induced in Lewis rats by immunization with bovine peripheral nerve myelin.
Gene_expression (expression) of CD40 in peripheral nerve associated with experimental autoimmune neuritis, immunization and neuritis
3) Confidence 0.72 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 0.71 Pain Relevance 0.49
Indeed, in all cases the titer of anti-GnRH antibodies correlated to the plasma level of sCD40, which is related to the CD40 expression and the activity of the CD40-CD40L signalling pathway.
Gene_expression (expression) of CD40 in plasma
4) Confidence 0.49 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2885307 Disease Relevance 0.50 Pain Relevance 0.09
In contrast, serum from cases 1 and 2 having lower anti-GnRH antibody titer and lower sCD40 levels had no significant effect on neuronal viability.
Gene_expression (levels) of sCD40 in neuronal
5) Confidence 0.48 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2885307 Disease Relevance 0.90 Pain Relevance 0.19
CD40 was measured by an ELISA kit developed for quantitative detection of sCD40 in human body fluids (Alexis© Biochemical, Bender MedSystems, Vienna, Austria).
Gene_expression (detection) of sCD40 in body
6) Confidence 0.48 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2885307 Disease Relevance 0.83 Pain Relevance 0.12
Increased plasma levels of sCD40 and their correlation with the extent of mucosal inflammation have been recently reported in patients with inflammatory bowel disease [23].
Gene_expression (levels) of sCD40 in bowel associated with mucositis and inflammation
7) Confidence 0.43 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2885307 Disease Relevance 0.72 Pain Relevance 0.17
Among the up-regulated pathways unique to the 20% CR, there was a dominance of signaling routes involved in energy metabolism (Butanoate, FA biosynthesis, KET, malate, malatex, ketone), immune function/cytokine activity (ANTI_CD44, nfkb, ctl, notch, lair) and development/differentiation (ST_Diff, cd40, notch, pkc, shh_lisa).
Gene_expression (biosynthesis) of cd40 in notch associated with cytokine
8) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.18 Pain Relevance 0.05
It was recently found that LSEC constitutively express all molecules necessary for antigen presentation: CD54, CD80, CD86, MHC class I and II, and CD40, and can function as antigen-presenting cells for CD4+ and CD8+ T cells [67,68].
Gene_expression (express) of CD40 in CD86
9) Confidence 0.18 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.17 Pain Relevance 0.14
Addition of simvastatin significantly reduced CD40 expression as well as platelet adhesion to fibrillating atria.
Gene_expression (expression) of CD40 in platelet associated with adhesions
10) Confidence 0.18 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2704895 Disease Relevance 1.17 Pain Relevance 0.04
AF was associated with a significant increase of endocardial CD40 expression (293.1 ± 55.1 pg/ml vs. 230.9 ± 53.3 pg/ml; p < 0.01), and platelet–endocardial adhesion compared with sinus rhythm atria (10.8 ± 2.2 vs. 5.2 ± 1.3 platelet CD41 AU; p < 0.01).
Gene_expression (expression) of CD40 in platelet associated with heart arrhythmia and adhesions
11) Confidence 0.18 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2704895 Disease Relevance 0.85 Pain Relevance 0.03
Chronic AF acutely upregulates CD40 expression as well as platelet adhesion to the endocardium.
Gene_expression (expression) of CD40 in endocardium associated with heart arrhythmia and adhesions
12) Confidence 0.18 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2704895 Disease Relevance 0.68 Pain Relevance 0.04

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