INT140930

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.26
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40) molecular_function (Cd40)
Anatomy Link Frequency
lymph nodes 2
platelet 2
bowel 2
endocardium 2
Cd40 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 12 99.84 Very High Very High Very High
Inflammation 104 98.00 Very High Very High Very High
Sciatic nerve 1 91.68 High High
fibrosis 12 82.96 Quite High
spastic colon 7 35.00 Quite Low
Inflammatory marker 10 10.72 Low Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
abdominal pain 11 5.00 Very Low Very Low Very Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 12 99.84 Very High Very High Very High
Heart Arrhythmia 574 99.82 Very High Very High Very High
Disease 12 99.76 Very High Very High Very High
Adhesions 7 99.16 Very High Very High Very High
Immunization 2 98.82 Very High Very High Very High
Mucositis 1 98.32 Very High Very High Very High
Inflammatory Bowel Disease 1 95.68 Very High Very High Very High
Autoimmune Disease 3 95.12 Very High Very High Very High
INFLAMMATION 126 93.08 High High
Thrombosis 2 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In draining lymph nodes, highest level of CD40L expression was seen on day 7 post immunization (p.i.), i.e. before onset of clinical signs of EAN, while CD40 expression was increased on day 14 p.i., i.e. at peak of clinical disease.
Positive_regulation (increased) of Gene_expression (expression) of CD40 in lymph nodes associated with immunization, disease and neuritis
1) Confidence 0.64 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 0.99 Pain Relevance 0.75
Increased plasma levels of sCD40 and their correlation with the extent of mucosal inflammation have been recently reported in patients with inflammatory bowel disease [23].
Positive_regulation (Increased) of Gene_expression (levels) of sCD40 in bowel associated with mucositis and inflammation
2) Confidence 0.33 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2885307 Disease Relevance 0.73 Pain Relevance 0.17
Chronic AF acutely upregulates CD40 expression as well as platelet adhesion to the endocardium.
Positive_regulation (upregulates) of Gene_expression (expression) of CD40 in endocardium associated with heart arrhythmia and adhesions
3) Confidence 0.16 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2704895 Disease Relevance 0.68 Pain Relevance 0.04
AF was associated with a significant increase of endocardial CD40 expression (293.1 ± 55.1 pg/ml vs. 230.9 ± 53.3 pg/ml; p < 0.01), and platelet–endocardial adhesion compared with sinus rhythm atria (10.8 ± 2.2 vs. 5.2 ± 1.3 platelet CD41 AU; p < 0.01).
Positive_regulation (increase) of Gene_expression (expression) of CD40 in platelet associated with heart arrhythmia and adhesions
4) Confidence 0.12 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2704895 Disease Relevance 0.86 Pain Relevance 0.03

General Comments

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