INT140931

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 5.20
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40lg) extracellular region (Cd40lg) plasma membrane (Cd40lg)
molecular_function (Cd40lg)
Anatomy Link Frequency
lymph nodes 1
sciatic nerves 1
dendritic cells 1
peripheral nerve 1
cell line cells 1
Cd40lg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 4 99.60 Very High Very High Very High
Neuritis 48 98.80 Very High Very High Very High
imagery 90 88.84 High High
positron emission tomography 24 88.68 High High
Inflammation 4 74.72 Quite High
cva 4 36.32 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Demyelination 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 174 99.84 Very High Very High Very High
Immunization 8 99.04 Very High Very High Very High
Disease 6 98.84 Very High Very High Very High
Experimental Autoimmune Neuritis 48 98.80 Very High Very High Very High
Malignant Neoplastic Disease 2 75.32 Quite High
INFLAMMATION 4 74.72 Quite High
Glioblastoma 18 71.20 Quite High
Residual Neoplasm 4 69.36 Quite High
Glioma 68 50.40 Quite High
Radiation Sickness 56 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In draining lymph nodes, highest level of CD40L expression was seen on day 7 post immunization (p.i.), i.e. before onset of clinical signs of EAN, while CD40 expression was increased on day 14 p.i., i.e. at peak of clinical disease.
Gene_expression (expression) of CD40L in lymph nodes associated with immunization, disease and neuritis
1) Confidence 0.61 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 0.86 Pain Relevance 0.61
After co-culture with EAN rat B cells bearing CD40, P0 peptide 180-199-specific T cell line cells exhibited a rapid down-regulation of CD40L expression.
Gene_expression (expression) of CD40L in cell line cells associated with neuritis
2) Confidence 0.61 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 1.08 Pain Relevance 1.00
In contrast, both CD40 and CD40L expressing cells in sciatic nerves, a target organ of EAN, peaked on day 14 p.i., large numbers of both expressing cells were mainly detected on day 14-21 p.i.
Gene_expression (expressing) of CD40L in sciatic nerves associated with sciatic nerve and neuritis
3) Confidence 0.61 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 1.01 Pain Relevance 0.78
The expression of co-stimulatory molecules CD40 and CD40L was examined over the course of experimental autoimmune neuritis (EAN) induced in Lewis rats by immunization with bovine peripheral nerve myelin.
Gene_expression (expression) of CD40L in peripheral nerve associated with experimental autoimmune neuritis, immunization and neuritis
4) Confidence 0.61 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 0.71 Pain Relevance 0.49
Investigators have shown effective sensitization of T-cells with profound antitumor effects when CD40 ligand (CD40L) is expressed in tumor cells [49].
Gene_expression (expressed) of CD40L in T-cells associated with cancer
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.75 Pain Relevance 0.23
Expression of CD40L also helped maturation of dendritic cells.
Gene_expression (Expression) of CD40L in dendritic cells
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.80 Pain Relevance 0.22

General Comments

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