INT140932

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 4.19
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40) molecular_function (Cd40)
Anatomy Link Frequency
T cell 3
sciatic nerves 1
Cd40 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 48 100.00 Very High Very High Very High
Sciatic nerve 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 48 100.00 Very High Very High Very High
Disease 4 99.20 Very High Very High Very High
Immunization 8 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated experimental autoimmune neuritis in Lewis rats.
CD40 Binding (interaction) of in T cell associated with experimental autoimmune neuritis and neuritis
1) Confidence 0.44 Published 2007 Journal Neurobiol. Dis. Section Title Doc Link 17188497 Disease Relevance 1.01 Pain Relevance 0.79
The results indicate that CD40L-CD40 interactions are involved in the initiation of the antigen-specific T cell responses associated with the generation and development of EAN, and may mediate autoantibody production in EAN.
CD40 Binding (interactions) of in T cell associated with neuritis
2) Confidence 0.44 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 1.13 Pain Relevance 1.03
In contrast, both CD40 and CD40L expressing cells in sciatic nerves, a target organ of EAN, peaked on day 14 p.i., large numbers of both expressing cells were mainly detected on day 14-21 p.i.
CD40 Binding (peaked) of in sciatic nerves associated with sciatic nerve and neuritis
3) Confidence 0.34 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 1.03 Pain Relevance 0.80
Evidently, B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated EAN of Lewis rats.
CD40 Binding (interaction) of in T cell associated with neuritis
4) Confidence 0.34 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 1.03 Pain Relevance 0.98

General Comments

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