INT140942

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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 1.37
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
reproductive organ 3
brain 1
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 52 100.00 Very High Very High Very High
antagonist 8 89.16 High High
agonist 8 88.56 High High
Versed 2 38.32 Quite Low
Enkephalin 2 25.00 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 10 99.26 Very High Very High Very High
Sepsis 37 98.86 Very High Very High Very High
Breast Cancer 6 79.28 Quite High
Delayed Puberty 2 77.88 Quite High
Repression 2 76.00 Quite High
Targeted Disruption 4 73.32 Quite High
Disease 2 38.32 Quite Low
Endometriosis (extended) 2 37.40 Quite Low
Advanced Or Metastatic Breast Cancer 2 36.64 Quite Low
Infection 2 32.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Regulation (affected) of Transcription (levels) of IGF-I in reproductive organ associated with urological neuroanatomy
1) Confidence 0.32 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.47 Pain Relevance 0
In established sepsis, nutrition and the route of administration of nutrition influences the circulating cytokine patterns and expression of mRNA of SOCS proteins, GHR and IGF-I.
Regulation (influences) of Transcription (expression) of IGF-I associated with sepsis and cytokine
2) Confidence 0.21 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206515 Disease Relevance 0.15 Pain Relevance 0.22
In this study we examined the effects of these compounds on the mRNA levels of the GH receptor/GH binding protein, IGF-I, ER?
Spec (examined) Regulation (effects) of Transcription (levels) of IGF-I
3) Confidence 0.19 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.21 Pain Relevance 0.17
We studied the effects on mRNA levels of the growth hormone (GH) receptor, insulin-like growth factor-I (IGF-I), ER?
Spec (like) Regulation (effects) of Transcription (levels) of growth factor-I
4) Confidence 0.17 Published 2003 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC156658 Disease Relevance 0.08 Pain Relevance 0.04
We investigated effects of pre- and postnatal exposure to 4-MBC in the same rat offspring at brain and reproductive organ levels. 4-MBC (7, 24, 47 mg/kg/day) was administered in chow to the parent generation before mating, during gestation and lactation, and to the offspring until adulthood. mRNA of estrogen target genes involved in control of sexual behavior and gonadal functions was measured by real-time RT-PCR in ventromedial hypothalamic nucleus (VMH) and medial preoptic area (MPO) of adult offspring. 4-MBC exposure affected mRNA levels of ER alpha, progesterone receptor (PR), preproenkephalin (PPE) and insulin-like growth factor-I (IGF-I) in a sex- and region-specific manner.
Regulation (affected) of in brain Transcription (levels) of IGF-I in reproductive organ associated with urological neuroanatomy
5) Confidence 0.11 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.47 Pain Relevance 0

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