INT140949

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.23
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
epithelial cells 2
heart 2
MPO 2
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 15 98.12 Very High Very High Very High
anesthesia 4 92.68 High High
antagonist 12 83.68 Quite High
anticonvulsant 17 83.44 Quite High
carbamazepine 18 76.00 Quite High
Dopamine 46 43.60 Quite Low
sodium channel 15 37.52 Quite Low
Enkephalin 1 25.00 Low Low
Gabapentin 2 13.32 Low Low
Lamotrigine 4 8.32 Low Low
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Heart Rate Under Development 2 99.02 Very High Very High Very High
Cancer 9 99.00 Very High Very High Very High
Urological Neuroanatomy 6 98.24 Very High Very High Very High
Decapitation 3 91.92 High High
Hypothermia 1 84.52 Quite High
Hyponatremia 2 83.84 Quite High
Death 1 80.64 Quite High
Anaemia 1 65.04 Quite High
Epilepsy 17 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acute induction of PR mRNA, and repression (at 6 h) of PPE mRNA by E2 was enhanced by 4-MBC in male and female VMH and female MPO, whereas male MPO exhibited reduced responsiveness of both genes.
Positive_regulation (enhanced) of Positive_regulation (induction) of PR in MPO associated with repression and urological neuroanatomy
1) Confidence 0.59 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.55 Pain Relevance 0
Stimulation of PR in mammary epithelial cells is another typical effect of E2, which we observed in the animals treated with both E2 doses and GEN high; however, we counted significantly fewer PR-expressing cells in the E2 high tissues compared with the E2 low tissues.
Positive_regulation (effect) of Positive_regulation (Stimulation) of PR in epithelial cells
2) Confidence 0.28 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.18 Pain Relevance 0
We believe that 2.5 h is sufficient for the D1 agonist to induce Fos expression via ER dependent pathways, as vaginocervical stimulation is able to induce Fos expression via dopaminergic activation of PR [35] within 1h [36].
Positive_regulation (induce) of Positive_regulation (activation) of PR associated with agonist
3) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.09 Pain Relevance 0.21
Electrocardiogram changes, specifically a mild prolongation of the PR interval, have been observed in patients taking eslicarbazepine.29 In recommending approval of eslicarbazepine in Europe, the European Medicines Agency advised a contraindication to the administration of eslicarbazepine to patients with 2nd or 3rd degree heart block and caution with co-administration of any drugs known to increase the PR interval.29
Positive_regulation (known) of Positive_regulation (increase) of PR in heart associated with heart rate under development
4) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857610 Disease Relevance 0.41 Pain Relevance 0.21

General Comments

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