INT14095

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Context Info
Confidence 0.33
First Reported 1991
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.98
Pain Relevance 4.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Vsig2, Coq10a) biological_process (Vsig2, Coq10a) cellular_component (Coq10a)
Anatomy Link Frequency
DRG 1
Vsig2 (Mus musculus)
Coq10a (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 13 99.36 Very High Very High Very High
opioid receptor 12 99.28 Very High Very High Very High
action potential duration 6 99.08 Very High Very High Very High
Morphine 11 97.72 Very High Very High Very High
Opioid 21 97.04 Very High Very High Very High
MU agonist 5 96.28 Very High Very High Very High
analgesia 6 96.12 Very High Very High Very High
Potency 2 93.32 High High
antagonist 2 92.04 High High
tolerance 4 88.16 High High
Disease Link Frequency Relevance Heat
Vibrio Infection 5 99.84 Very High Very High Very High
Ganglion Cysts 14 99.36 Very High Very High Very High
Hyperalgesia 6 94.40 High High
Nociception 2 89.64 High High
Drug Dependence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, treatment of DRG neurons with the non-toxic B-subunit of cholera toxin (CTX-B) which binds selectively to GM1, blocked the excitatory, but not inhibitory, effects of morphine and other bimodally-acting opioid agonists, thereby resulting in a net increase in inhibitory opioid potency.
CTX-B Binding (binds) of GM1 in DRG associated with dorsal root ganglion, mu agonist, vibrio infection, opioid, potency and morphine
1) Confidence 0.33 Published 2001 Journal Brain Res. Section Abstract Doc Link 11689159 Disease Relevance 0.69 Pain Relevance 1.36
Low-dose NTX selectively blocks excitatory opioid receptors at their recognition site, whereas CTX-B binds to, and interferes with, a putative allosteric GM1 regulatory site on excitatory opioid receptors.
CTX-B Binding (binds) of GM1 associated with opioid receptor
2) Confidence 0.22 Published 2001 Journal Brain Res. Section Abstract Doc Link 11689159 Disease Relevance 0.61 Pain Relevance 1.96
Since CTX-B binds with selective high affinity to GM1 ganglioside located on the cell surface, the results suggest that GM1 plays an essential role in regulating excitatory opioid receptor functions.
CTX-B Binding (binds) of GM1 associated with opioid receptor
3) Confidence 0.08 Published 1991 Journal Brain Res. Section Abstract Doc Link 1685937 Disease Relevance 0.68 Pain Relevance 1.23

General Comments

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