INT140966

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (NFKB1, CPOX) cytoplasm (NFKB1, CPOX) nucleoplasm (NFKB1)
small molecule metabolic process (CPOX) cytosol (NFKB1) signal transduction (NFKB1)
NFKB1 (Homo sapiens)
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 99.78 Very High Very High Very High
Hyperalgesia 5 99.20 Very High Very High Very High
cINOD 3 99.04 Very High Very High Very High
diclofenac 2 83.52 Quite High
Pain 1 66.04 Quite High
Antihyperalgesic 1 52.36 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 99.20 Very High Very High Very High
Injury 2 95.00 High High
Pain 1 66.04 Quite High
INFLAMMATION 1 54.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that the freeze lesion model is sensitive to NSAIDs including selective COX-2 inhibitors, and that NF-kappaB-dependent COX-2 upregulation contributes to the hyperalgesia in this model.
NF-kappaB-dependent Positive_regulation (dependent) of Positive_regulation (upregulation) of COX associated with hyperalgesia, cinod and cox-2 inhibitor
1) Confidence 0.08 Published 2007 Journal Pain Section Abstract Doc Link 17189672 Disease Relevance 0.66 Pain Relevance 0.80

General Comments

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