INT14097

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 5.14
Pain Relevance 6.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
SON 10
PVN 4
neurons 2
plasma 1
medial forebrain bundle 1
Son (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Locus ceruleus 1 99.98 Very High Very High Very High
withdrawal 6 99.90 Very High Very High Very High
narcan 7 99.84 Very High Very High Very High
qutenza 18 99.82 Very High Very High Very High
anesthesia 5 99.76 Very High Very High Very High
Morphine 8 99.68 Very High Very High Very High
analgesia 7 99.04 Very High Very High Very High
amygdala 14 98.92 Very High Very High Very High
Acupuncture 68 98.64 Very High Very High Very High
Glutamate 8 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypernatremia 1 99.06 Very High Very High Very High
Nociception 14 99.04 Very High Very High Very High
Stress 16 98.96 Very High Very High Very High
Polycystic Ovary Syndrome 89 98.52 Very High Very High Very High
Myocardial Infarction 39 97.96 Very High Very High Very High
Pain 2 94.04 High High
Sprains And Strains 1 92.72 High High
Decapitation 6 89.20 High High
Appetite Loss 6 84.52 Quite High
Anorexia 1 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrical stimulation of the SON or microinjection of a small dose L-glutamate sodium into the SON enhanced acupuncture analgesia in a dose-dependent manner, while cauterization of the SON weakened acupuncture analgesia.
Positive_regulation (stimulation) of SON in SON associated with glutamate, acupuncture and analgesia
1) Confidence 0.61 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355646 Disease Relevance 0.19 Pain Relevance 1.21
Acute surgery for isolation of vagus nerves and anesthesia for 90 min increased the number of Fos positive cells in PVN, SON and MnPO of both sham-operated rats and rats with HF.
Positive_regulation (increased) of SON in MnPO associated with anesthesia and myocardial infarction
2) Confidence 0.43 Published 2000 Journal Brain Res. Section Abstract Doc Link 10814730 Disease Relevance 0.70 Pain Relevance 0.10
Electrical stimulation of the SON or microinjection of a small dose of L-glutamate sodium into the SON elevated the nociceptive threshold in a dose-dependent manner, while cauterization of the SON decreased the nociceptive threshold.
Positive_regulation (stimulation) of SON in SON associated with nociception and glutamate
3) Confidence 0.41 Published 2008 Journal Life Sci. Section Abstract Doc Link 18062994 Disease Relevance 0.36 Pain Relevance 0.20
Electrical stimulation of the supraoptic nucleus (SON) for 3 min in dexamethasone-morphine-pentobarbital-pretreated rats raised the plasma level of corticosterone; 4 days after placing a surgical lesion in the hypothalamic paraventricular nuclei (PVN) electrical stimulation of the SON failed to change the plasma level of corticosterone.
Positive_regulation (stimulation) of SON in supraoptic nucleus associated with dexamethasone and morphine
4) Confidence 0.40 Published 1982 Journal Neurosci. Lett. Section Abstract Doc Link 7110634 Disease Relevance 0 Pain Relevance 0.14
Electrical stimulation of the locus coeruleus increased MHPG concentrations in the PVN, but not in the SON, whereas electrical stimulation of the medial forebrain bundle increased MHPG concentrations in both of these regions.
Neg (not) Positive_regulation (increased) of SON in medial forebrain bundle associated with locus ceruleus
5) Confidence 0.40 Published 1991 Journal Brain Res. Section Abstract Doc Link 1685939 Disease Relevance 0 Pain Relevance 0.29
During morphine withdrawal the increased electrical activity of SON neurones was also reduced both by i.c.v. verapamil and microdialysis application of verapamil or nifedipine into the SON.
Positive_regulation (increased) of SON in SON associated with withdrawal and morphine
6) Confidence 0.40 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10854904 Disease Relevance 0 Pain Relevance 0.78
The number of c-Fos-positive cells was significantly increased only at 2 h in the SON and PVN.
Positive_regulation (increased) of SON in PVN
7) Confidence 0.37 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15899256 Disease Relevance 0 Pain Relevance 0.09
The results showed a negative feedback regulation of the spontaneous ACh release through the activation of muscarinic receptors in the SON.
Positive_regulation (activation) of SON in SON
8) Confidence 0.34 Published 1993 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8483297 Disease Relevance 0 Pain Relevance 0.20
Release of oxytocin within the SON, measured by microdialysis in conscious rats, was also increased by naloxone in late pregnancy but not before.
Neg (not) Positive_regulation (increased) of SON in SON associated with narcan
9) Confidence 0.34 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7623133 Disease Relevance 0 Pain Relevance 0.77
These animals suffer from chronic hypernatremia and hyperosmolality, accompanied by sustained increase in OXY mRNA in PVN and SON and OXY levels in plasma.
Positive_regulation (increase) of SON in plasma associated with hypernatremia
10) Confidence 0.33 Published 2008 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 18773290 Disease Relevance 0.19 Pain Relevance 0.17
m) containing the paired SON were prepared as previously reported.23 Slices were maintained in Earle’s balanced salt solution, pH 7.2, at 37 °C supplemented with 24.6 mM glucose, 26.2 mM sodium bicarbonate, and 5 mg/L gentamicin and saturated with 95% O2?
Positive_regulation (paired) of SON
11) Confidence 0.30 Published 2008 Journal Journal of Proteome Research Section Body Doc Link PMC2646869 Disease Relevance 0.09 Pain Relevance 0
The capsaicin-induced activation of the hypothalamic PVN and SON neurons and the medial amygdaloid nucleus was attenuated in the NOS inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME) -pretreated animals in comparison with the inactive enantiomer D-NAME.
Positive_regulation (activation) of SON in neurons associated with qutenza
12) Confidence 0.30 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10880996 Disease Relevance 0 Pain Relevance 0.76
Subcutaneous capsaicin injection in male rats, compared with vehicle, caused a significant increase in Fos expression in the paraventricular nucleus (PVN), supraoptic nucleus (SON), and medial and cortical amygdala.
Positive_regulation (increase) of SON in supraoptic nucleus associated with qutenza and amygdala
13) Confidence 0.30 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10880996 Disease Relevance 0 Pain Relevance 0.74
The AVP hnRNA in the PVN and SON was also significantly increased 15, 30 min and 2 h after s.c. injection of formalin, though AVP mRNA did not change at any time points that we studied.
Positive_regulation (increased) of SON in SON
14) Confidence 0.30 Published 2001 Journal Auton Neurosci Section Abstract Doc Link 11474546 Disease Relevance 0.30 Pain Relevance 0.04
These results indicate that PACAP enhances Ca2+ entry via voltage-gated Ca2+ channels and increases [Ca2+]i, which, in turn, stimulates somatodendritic vasopressin release by directly activating PACAP receptors on SON neurons.
Positive_regulation (activating) of SON in neurons
15) Confidence 0.29 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9510056 Disease Relevance 0 Pain Relevance 0.19
Responses of MAP after severance of the SON and OPN in both the Control and the PCO groups were similar to those in rats with intact ovarian sympathetic nerves, when stimulating with an intensity of both 3 and 6 mA (Fig. 2B and 2D).
Positive_regulation (severance) of SON associated with polycystic ovary syndrome
16) Confidence 0.27 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC411056 Disease Relevance 0.63 Pain Relevance 0.22
There were no differences between Sham and ADX groups in Fos-OT double labeling in any subdivision of the PVN; however, in the SON, the number of Fos-OT double labeled cells was increased at all time-points after stress in the ADX group.
Positive_regulation (increased) of SON associated with stress
17) Confidence 0.26 Published 2007 Journal Stress Section Abstract Doc Link 17853060 Disease Relevance 0.57 Pain Relevance 0.07
PCPA pretreatment increased dF- and dNF-induced Fos-ir in the PVN, SON, and MnPO.
Positive_regulation (increased) of SON in MnPO
18) Confidence 0.16 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10666140 Disease Relevance 0.43 Pain Relevance 0.24
Acute surgery for isolation of vagus nerves and anesthesia for 90 min increased the number of Fos positive cells in PVN, SON and MnPO of both sham-operated rats and rats with HF.
Positive_regulation (increased) of SON in PVN associated with anesthesia and myocardial infarction
19) Confidence 0.14 Published 2000 Journal Brain Res. Section Abstract Doc Link 10814730 Disease Relevance 0.70 Pain Relevance 0.10
Acute surgery for isolation of vagus nerves and anesthesia for 90 min increased the number of Fos positive cells in PVN, SON and MnPO of both sham-operated rats and rats with HF.
Positive_regulation (increased) of SON in SON associated with anesthesia and myocardial infarction
20) Confidence 0.14 Published 2000 Journal Brain Res. Section Abstract Doc Link 10814730 Disease Relevance 0.70 Pain Relevance 0.10

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