INT140973

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.93
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 4
spinal cord 2
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 12 100.00 Very High Very High Very High
Spinal cord 6 98.92 Very High Very High Very High
antagonist 3 95.32 Very High Very High Very High
drug abuse 1 88.12 High High
depression 1 87.28 High High
Neuropathic pain 1 86.80 High High
anesthesia 1 83.80 Quite High
Dorsal horn 1 81.76 Quite High
neurotrophin 3 1 66.32 Quite High
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Frailty 9 100.00 Very High Very High Very High
Nociception 2 98.52 Very High Very High Very High
Injury 5 94.48 High High
Pressure And Volume Under Development 2 93.40 High High
Drug Dependence 1 88.12 High High
Depression 1 87.28 High High
Neuropathic Pain 1 86.80 High High
Disease 3 86.08 High High
Neurodegenerative Disease 1 83.00 Quite High
Ganglion Cysts 1 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIMS: To investigate whether local administration of nerve growth factor (NGF) decreases the mechanical threshold (MT) of putative nociceptive masseter afferent fibers as part of its mechanism of mechanical sensitization.
Spec (whether) Negative_regulation (decreases) of NGF Spec (whether) Binding (administration) of in nerve associated with nociception and nerve growth factor
1) Confidence 0.43 Published 2006 Journal J Orofac Pain Section Abstract Doc Link 17190031 Disease Relevance 0.10 Pain Relevance 0.09
AIMS: To investigate whether local administration of nerve growth factor (NGF) decreases the mechanical threshold (MT) of putative nociceptive masseter afferent fibers as part of its mechanism of mechanical sensitization.
Spec (whether) Negative_regulation (decreases) of nerve growth factor Spec (whether) Binding (administration) of in nerve associated with nociception and nerve growth factor
2) Confidence 0.43 Published 2006 Journal J Orofac Pain Section Abstract Doc Link 17190031 Disease Relevance 0.10 Pain Relevance 0.09
However, a combination of BDNF and GDNF (but not with NT-3 or NGF) given either 60 or 90 min after SCI significantly reduced the motor dysfunction and spinal cord pathology at 5 h.
Negative_regulation (reduced) of NGF Neg (not) Binding (combination) of in spinal cord associated with frailty and spinal cord
3) Confidence 0.37 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077567 Disease Relevance 1.14 Pain Relevance 0.40
Y1036 binds BDNF (K(D) = 3.5 +/- 0.3 microM) and NGF (K(D) = 3.0 +/- 0.4 microM) preventing either BDNF or NGF from interacting with their obligate receptor(s).
Negative_regulation (preventing) of NGF Binding (binds) of associated with nerve growth factor
4) Confidence 0.13 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19923440 Disease Relevance 0.60 Pain Relevance 0.59

General Comments

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