INT14098

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1989
Last Reported 2006
Negated 5
Speculated 4
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 4.01
Pain Relevance 12.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
brain 6
neurons 4
dorsal root ganglions 3
sensory neurons 2
spinal cord 2
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 116 100.00 Very High Very High Very High
qutenza 39 100.00 Very High Very High Very High
Neuropeptide 30 100.00 Very High Very High Very High
electroacupuncture 14 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
Cholecystokinin 3 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
nociceptor 1 100.00 Very High Very High Very High
Calcitonin gene-related peptide 17 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 6 99.84 Very High Very High Very High
Neuropathic Pain 14 99.78 Very High Very High Very High
Ganglion Cysts 20 98.24 Very High Very High Very High
Diabetes Mellitus 70 96.56 Very High Very High Very High
Diabetes Complications 3 87.92 High High
Hyperglycemia 2 82.80 Quite High
Injury 7 78.16 Quite High
Convulsion 5 76.68 Quite High
Poisoning 2 75.00 Quite High
Aggression 1 73.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization and immunocytochemistry were applied to investigate changes in the expression of somatostatin, neuropeptide Y, neurokinin B, cholecystokinin, dynorphin, and Met-enkephalin in the rat hippocampus after administration of a single peroral dose of trimethyltin hydroxide (9 mg/kg).
Spec (investigate) Regulation (changes) of Gene_expression (expression) of somatostatin in hippocampus associated with dynorphin, neuropeptide, somatostatin, hippocampus, enkephalin and cholecystokinin
1) Confidence 0.44 Published 1998 Journal Synapse Section Abstract Doc Link 9661251 Disease Relevance 0.29 Pain Relevance 0.50
[Effect of intraventricular injection of somatostatin on pain threshold, and contents of the monoamines, xanthine, hypoxanthine in rats brain].
Regulation ([Effect) of Gene_expression (injection) of somatostatin in brain associated with pain, pain threshold, somatostatin and monoamine
2) Confidence 0.43 Published 1991 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 1688090 Disease Relevance 0.19 Pain Relevance 0.85
Therefore, we determined somatostatin protein production and secretion levels, and biochemical and light microscopical changes following zinc supplementation in the gastrointestinal tract of streptozotocin (STZ)-diabetic rats.
Spec (determined) Regulation (changes) of Spec (determined) Gene_expression (production) of somatostatin associated with diabetes mellitus and somatostatin
3) Confidence 0.36 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1831851 Disease Relevance 0.72 Pain Relevance 0.14
No effect of kainate was observed in the expression of somatostatin receptor messenger RNAs in the cerebral cortex.
Neg (No) Regulation (effect) of Gene_expression (expression) of somatostatin in cerebral cortex associated with somatostatin and cerebral cortex
4) Confidence 0.35 Published 1995 Journal Neuroscience Section Abstract Doc Link 7617164 Disease Relevance 0.08 Pain Relevance 0.86
A transient expression of the neuropeptide somatostatin has been described in several brain areas during early ontogeny and several opioid peptides, such as leu-enkephalin, have also been found in the brain at this stage in development.
Regulation (described) of Gene_expression (expression) of somatostatin in brain associated with somatostatin, neuropeptide, enkephalin and opioid
5) Confidence 0.35 Published 1995 Journal Anat. Embryol. Section Abstract Doc Link 7625613 Disease Relevance 0 Pain Relevance 0.71
Effects of electroacupuncture on expression of somatostatin and preprosomatostatin mRNA in dorsal root ganglions and spinal dorsal horn in neuropathic pain rats.
Regulation (Effects) of Gene_expression (expression) of somatostatin in dorsal root ganglions associated with ganglion cysts, neuralgia, spinal dorsal horn, neuropathic pain, somatostatin and electroacupuncture
6) Confidence 0.35 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15970377 Disease Relevance 0.78 Pain Relevance 1.66
We also demonstrated that the regulation of somatostatin gene expression in mature sensory neurons is not affected by systemic capsaicin.
Regulation (regulation) of Gene_expression (expression) of somatostatin gene in sensory neurons associated with qutenza and somatostatin
7) Confidence 0.33 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971780 Disease Relevance 0.13 Pain Relevance 0.87
The influence of membrane depolarization on somatostatin secretion and protein synthesis by fetal and neonatal cerebrocortical neurons was studied.
Regulation (influence) of Gene_expression (synthesis) of somatostatin in neurons associated with somatostatin
8) Confidence 0.27 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2468735 Disease Relevance 0 Pain Relevance 0.13
Antral gastrin contents, somatostatin contents, gastrin mRNA expression, and somatostatin mRNA expression were not significantly affected by capsaicin pretreatment.
Neg (not) Regulation (affected) of Gene_expression (expression) of somatostatin associated with qutenza and somatostatin
9) Confidence 0.25 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.71
However, the expression of somatostatin messenger RNA was unaffected by the systemic administration of capsaicin.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of somatostatin associated with qutenza and somatostatin
10) Confidence 0.24 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971780 Disease Relevance 0.29 Pain Relevance 1.01
Therefore, we examined the effects of systemically administered capsaicin on the expression of the beta-preprotachykinin, gamma-preprotachykinin, somatostatin, calcitonin gene-related peptide, vasoactive intestinal polypeptide, galanin, neuropeptide Y and neurotrophin receptor family (trkA, trkB, trkC) genes in dorsal root ganglion neurons by in situ hybridization in adult rats.
Spec (examined) Regulation (effects) of Gene_expression (expression) of somatostatin in neurons associated with ganglion cysts, qutenza, root ganglion neuron, neuropeptide, somatostatin and calcitonin gene-related peptide
11) Confidence 0.24 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971780 Disease Relevance 0.15 Pain Relevance 0.73
Determination of hypothalamic somatostatin and GHRH content in the chronic experiment 4 h after the last drug administration revealed a marked decrease in GHRH in the mid-pubertal rats and a slight decrease in the prepubertal rats (1.78 +/- 0.32 vs 3.15 +/- 0.31 and 2.01 +/- 0.30 vs 2.35 +/- 0.15 ng/hypothalamus; P less than 0.005 and P less than 0.05 respectively) whereas somatostatin levels were not altered.
Neg (not) Regulation (altered) of Gene_expression (levels) of somatostatin in hypothalamus associated with somatostatin
12) Confidence 0.23 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 1686052 Disease Relevance 0 Pain Relevance 0.62
[Effect of ACTH on the expression of somatostatin and c-fos in the spinal cord and formalin evoked pain response].
Regulation ([Effect) of Gene_expression (expression) of somatostatin in spinal cord associated with pain, nociceptor, somatostatin and spinal cord
13) Confidence 0.23 Published 1999 Journal Sheng Li Xue Bao Section Title Doc Link 11972177 Disease Relevance 0.34 Pain Relevance 1.11
The present work was to explore if beyond neuropeptide release, cisplatin at a treatment schedule attaining sensory neuropathy, produced changes in the expression of the receptors of sensory neuropeptides such as somatostatin, calcitonin gene-related peptide (CGRP) and substance P (SP) in bronchial tissue of the rat.
Regulation (changes) of Gene_expression (expression) of somatostatin associated with neuropathic pain, somatostatin, neuropeptide, substance p, calcitonin gene-related peptide and neuropeptide release
14) Confidence 0.23 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.27 Pain Relevance 0.57
Fourteen days of hypergravity (hyperG) exposure resulted in significant increases in thyrotropin-releasing hormone (TRH) content of brainstem and cerebellum, but no changes in levels of other neuropeptides (beta-endorphin, cholecystokinin, met-enkephalin, somatostatin, and substance P) examined in these areas were found, nor were TRH levels significantly changed in any other brain regions investigated.
Neg (no) Regulation (changes) of Spec (examined) Gene_expression (levels) of somatostatin in brain associated with medulla, somatostatin, neuropeptide, enkephalin, cholecystokinin and substance p
15) Confidence 0.19 Published 1998 Journal Biol Signals Recept Section Abstract Doc Link 9873155 Disease Relevance 0 Pain Relevance 0.80
Effects of electroacupuncture on expression of somatostatin and preprosomatostatin mRNA in dorsal root ganglions and spinal dorsal horn in neuropathic pain rats.
Regulation (Effects) of in spinal Gene_expression (expression) of somatostatin in dorsal root ganglions associated with ganglion cysts, neuralgia, spinal dorsal horn, neuropathic pain, somatostatin and electroacupuncture
16) Confidence 0.12 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15970377 Disease Relevance 0.78 Pain Relevance 1.66

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox