INT140983

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.06
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ihh) peptidase activity (Ihh) extracellular region (Ihh)
plasma membrane (Ihh) embryo development (Ihh) cell-cell signaling (Ihh)
Anatomy Link Frequency
articular 2
patterning 2
chondrocytes 1
Ihh (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 100.00 Very High Very High Very High
Snapping jaw 14 98.32 Very High Very High Very High
dexamethasone 188 93.96 High High
Inflammation 20 5.00 Very Low Very Low Very Low
cytokine 18 5.00 Very Low Very Low Very Low
chemokine 18 5.00 Very Low Very Low Very Low
diabetic neuropathy 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 14 98.32 Very High Very High Very High
Leukemia 6 93.72 High High
Diabetes Mellitus 308 84.60 Quite High
Apoptosis 14 83.40 Quite High
Multiple Sclerosis 2 51.00 Quite High
Viral Meningitis 2 50.80 Quite High
Multiple Hereditary Exostoses 45 50.00 Quite Low
Osteoarthritis 5 44.56 Quite Low
Autoimmune Disease 30 27.16 Quite Low
Repression 3 5.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In wild-type mouse embryos, Ihh expression was already strong in condylar cartilage by embryonic day (E) 15.5, and expression of Ihh receptors and effector genes (Gli1, Gli2, Gli3, and PTHrP) indicated that Ihh range of action normally reached apical condylar tissue layers, including polymorphic chondroprogenitor layer and articular disc primordia.
Gene_expression (expression) of Ihh in articular
1) Confidence 0.78 Published 2007 Journal Dev. Dyn. Section Abstract Doc Link 17191253 Disease Relevance 0.42 Pain Relevance 0.42
In wild-type mouse embryos, Ihh expression was already strong in condylar cartilage by embryonic day (E) 15.5, and expression of Ihh receptors and effector genes (Gli1, Gli2, Gli3, and PTHrP) indicated that Ihh range of action normally reached apical condylar tissue layers, including polymorphic chondroprogenitor layer and articular disc primordia.
Gene_expression (expression) of Ihh in articular
2) Confidence 0.78 Published 2007 Journal Dev. Dyn. Section Abstract Doc Link 17191253 Disease Relevance 0.43 Pain Relevance 0.43
Specifically, we evaluated the expression patterns of Indian hedgehog (Ihh), Tissue inhibitor of matrix metalloproteinase 4 (Timp4), Cyclin-dependent kinase inhibitor 1C (Cdkn1c), which contains a GC response element in its promoter [57], Integrin beta like 1 protein (Itgbl1), GC receptor (Nr3c1), Integrin beta 1 (Itgb1) and Kruppel-like factor 15 (Klf15) over 0, 6, 12, and 24 hrs of culture with or without DEX treatment.
Gene_expression (expression) of Ihh associated with metalloproteinase and dexamethasone
3) Confidence 0.57 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.21
Probes for Indian hedgehog (Ihh), Tissue inhibitor of matrix metalloproteinase 4 (Timp4), Cyclin-dependent kinase inhibitor 1C (Cdkn1c, p57), Integrin beta like 1 protein (Itgbl1), GC receptor (Nr3c1), Integrin beta 1 (Itgb1) and Kruppel-like factor 15 (Klf15) were assayed using the TaqMan® gene expression assays in accordance with the manufacturers directions.
Gene_expression (expression) of Ihh associated with metalloproteinase
4) Confidence 0.49 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.09
Hh signaling, including Ihh (Indian hedgehog), is critical to both patterning in early pancreas development and in regulating insulin production in differentiated ?
Gene_expression (signaling) of Ihh in patterning
5) Confidence 0.48 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.63 Pain Relevance 0
Hh signaling, including Ihh (Indian hedgehog), is critical to both patterning in early pancreas development and in regulating insulin production in differentiated ?
Gene_expression (hedgehog) of Ihh in patterning
6) Confidence 0.48 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.58 Pain Relevance 0
During normal embryonic growth IHh, expressed in the transition zone, is involved in a paracrine feedback loop regulating proliferation and differentiation of chondrocytes and bony collar formation in the growth plate (Fig. 5A).
Gene_expression (expressed) of IHh in chondrocytes
7) Confidence 0.17 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0 Pain Relevance 0

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