INT140984

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.81
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ihh) peptidase activity (Ihh) extracellular region (Ihh)
plasma membrane (Ihh) embryo development (Ihh) cell-cell signaling (Ihh)
Anatomy Link Frequency
Parathyroid 1
Ihh (Mus musculus)
Pain Link Frequency Relevance Heat
Snapping jaw 8 87.00 High High
Pain 5 63.04 Quite High
imagery 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 26 98.16 Very High Very High Very High
Hemifacial Microsomia 2 94.08 High High
Chondroma 42 91.84 High High
Osteopoikilosis 26 91.12 High High
Cleidocranial Dysplasia 4 90.36 High High
Heterotopic Ossification 1 87.68 High High
Enchondromatosis 58 87.00 High High
Temporomandibular Joint Syndrome 8 87.00 High High
Apoptosis 1 78.68 Quite High
Multiple Hereditary Exostoses 62 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings indicate that Ndst1-dependent HS sulfation is critical for mandibular and TMJ development and allows HS-PGs to exert their roles via regulation of Ihh signaling topography and action.
Regulation (regulation) of Ihh
1) Confidence 0.54 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20554886 Disease Relevance 0.43 Pain Relevance 0.07
These severe defects were partially corrected in double Ihh(-/-)/Gli3(-/-) mutants, signifying that Ihh action is normally modulated and delimited by Gli3 and Gli3(R) in particular.
Regulation (modulated) of Ihh
2) Confidence 0.45 Published 2007 Journal Dev. Dyn. Section Abstract Doc Link 17191253 Disease Relevance 0.42 Pain Relevance 0.42
Parathyroid hormone-related protein (PTHrP) and Indian Hedgehog (IHH) acting on their respective receptors PTHR1 and PTCH1 exert a tightly coupled signaling relay, which is critical for the regulation of endochondral ossification (Figure 2).
Regulation (acting) of IHH in Parathyroid
3) Confidence 0.19 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 0.97 Pain Relevance 0
The nature of the tumour suppressor effects of the heparan sulphate biosynthesis is not entirely clear, however the regulation of Ihh signalling was proposed to play an important role [11].
Regulation (regulation) of Ihh associated with cancer
4) Confidence 0.16 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2912259 Disease Relevance 0.92 Pain Relevance 0.06
Remarkably, in Ttv mutants only the IHh signalling is affected, while other HSPG-dependent pathways, like FGF and WNT signalling, are not.
Regulation (affected) of IHh
5) Confidence 0.13 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0.07 Pain Relevance 0

General Comments

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