INT140991

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.55
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) nucleolus (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
liver 2
SNL 1
skeletal muscle 1
brain 1
third ventricle 1
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 7 100.00 Very High Very High Very High
Spinal cord 5 99.92 Very High Very High Very High
cytokine 5 98.98 Very High Very High Very High
allodynia 1 97.44 Very High Very High Very High
Thermal hyperalgesia 1 96.88 Very High Very High Very High
intrathecal 1 95.40 Very High Very High Very High
Potency 20 86.68 High High
Neuropathic pain 2 81.44 Quite High
ischemia 3 80.52 Quite High
Peripheral nerve injury 2 80.12 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 257 100.00 Very High Very High Very High
Apoptosis 173 100.00 Very High Very High Very High
Ocular Hypertension 91 99.98 Very High Very High Very High
Neuropathic Pain 3 97.44 Very High Very High Very High
Hyperalgesia 1 96.88 Very High Very High Very High
Glaucoma 80 95.08 Very High Very High Very High
Obesity 10 92.60 High High
Injury 2 87.84 High High
Middle Cerebral Artery Infarction 1 87.68 High High
Disease 254 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STAT3 pathway blockade with Janus kinase 2 inhibitor AG490 attenuated both mechanical allodynia and thermal hyperalgesia in SNL rats.
Negative_regulation (blockade) of STAT3 in SNL associated with allodynia and thermal hyperalgesia
1) Confidence 0.53 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18636982 Disease Relevance 0.67 Pain Relevance 0.91
To examine the role of the hypothalamus in mediating the effects of peripherally administered HN analogue, we infused HNGF6A peripherally in the presence of hypothalamic inhibition of STAT-3 and studied glucose fluxes under insulin clamps.
Negative_regulation (inhibition) of STAT-3 in hypothalamus
2) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
Furthermore, the effect on HGP was completely blocked by central STAT-3 inhibition (Fig. 6B) while effects on skeletal muscle were attenuated (Fig. 6C).
Negative_regulation (inhibition) of STAT-3 in skeletal muscle
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
Likewise, we show that co-infusion of a STAT-3 inhibitor with HN into the third ventricle completely attenuates the ability of HN to modulate peripheral insulin action.
Negative_regulation (inhibitor) of STAT-3 in third ventricle
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.35 Pain Relevance 0
The central effects of HN on insulin action were associated with activation of hypothalamic STAT-3 signaling; effects that were negated by co-inhibition of hypothalamic STAT-3.
Negative_regulation (inhibition) of STAT-3
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.88 Pain Relevance 0
Inhibition of hypothalamic STAT-3 completely negated the effects of IV HN analog on liver, suggesting that the hepatic actions of HN are centrally mediated.
Negative_regulation (Inhibition) of STAT-3 in liver
6) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.85 Pain Relevance 0
Stat3 activation by diabetes and subsequent blood retinal barrier damage can be prevented by simvastatin treatment [57].
Negative_regulation (prevented) of Stat3 in blood associated with diabetes mellitus
7) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.62 Pain Relevance 0.03
This has been directly demonstrated in rats by co-infusion of a STAT-3 inhibitor with leptin which resulted in attenuation of the actions of leptin on food intake and glucose metabolism [23].
Negative_regulation (inhibitor) of STAT-3
8) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.32 Pain Relevance 0
A primed-continuous ICV infusion of HN, F6AHN (total dose of 20 ug), dimerization deficient (DD) HN, STAT-3 inhibitor (75 pmol) , or artificial cerebro-spinal fluid (aCSF) was initiated at t?
Negative_regulation (inhibitor) of STAT-3 in spinal
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.26 Pain Relevance 0.07
A subgroup of animals that received IV HNGF6A also received ICV STAT-3 inhibitor [23].
Negative_regulation (received) of STAT-3
10) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0.08
Indeed, when STAT-3 signaling was inhibited in the hypothalamus, the effects of peripherally administered HN analog on liver was completely abolished, once again emphasizing the role of the hypothalamus in mediating the hepatic effects of HN and its analogues.
Negative_regulation (inhibited) of STAT-3 in liver
11) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.34 Pain Relevance 0
In the presence of hypothalamic STAT-3 inhibition, the GIR in response to peripheral HNGF6A was similar to controls (Fig. 6A).
Negative_regulation (inhibition) of STAT-3
12) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
H9C2 cells raised in 25 mmol/l compared with 5.56 mmol/l glucose media also demonstrated reduced morphine-induced P-GSK3beta, P-Akt, P-STAT3, and P-ERK1 after 15 min.
Negative_regulation (reduced) of P-STAT3 associated with morphine
13) Confidence 0.26 Published 2007 Journal Diabetes Section Abstract Doc Link 17192474 Disease Relevance 0.54 Pain Relevance 0.59
We analyzed the changes in neurological severity scores, infarct volume, number of apoptotic neurons, and the expression of G-CSF receptor, phosphorylated signal transducer and activator of transcription 3 (pSTAT3), cellular inhibitor of apoptosis protein 2 (cIAP2), Bcl-2, and Bax in the brain tissue.
Negative_regulation (inhibitor) of pSTAT3 in brain associated with apoptosis
14) Confidence 0.25 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18832793 Disease Relevance 1.82 Pain Relevance 0.16
Ciliary neurotrophic factor (CNTF), which is an interleukin-6 cytokine injected into the eyes of rats with increased IOP reduced apoptosis, phosphorylated STAT-3, and reduced the activity of caspase-3.
Negative_regulation (reduced) of STAT-3 in eyes associated with apoptosis, ocular hypertension and cytokine
15) Confidence 0.09 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792620 Disease Relevance 0.91 Pain Relevance 0.21

General Comments

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