INT141

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Context Info
Confidence 0.48
First Reported 1975
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 3.53
Pain Relevance 11.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
striatum 4
arcuate nucleus 2
dendrites 1
dopaminergic neurons 1
hippocampus 1
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 38 100.00 Very High Very High Very High
Catecholamine 10 100.00 Very High Very High Very High
Serotonin 19 99.88 Very High Very High Very High
Neuropeptide 12 99.76 Very High Very High Very High
Morphine 28 99.64 Very High Very High Very High
Dopamine 59 99.60 Very High Very High Very High
adenocard 4 99.30 Very High Very High Very High
Substantia nigra 33 99.08 Very High Very High Very High
Opioid 5 98.92 Very High Very High Very High
Analgesic 5 96.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pheochromocytoma 9 99.76 Very High Very High Very High
Ganglion Cysts 14 99.24 Very High Very High Very High
Shock 4 95.00 High High
Decapitation 2 88.64 High High
Parkinson's Disease 43 87.96 High High
Gastroparesis 1 84.48 Quite High
Bordatella Infection 1 77.96 Quite High
Disease 14 73.92 Quite High
Pain 2 73.76 Quite High
Depression 10 68.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Competition displacement binding assays suggest that protein binding to the -102/-73 region of the TH gene is critically dependent on the TH E1 sequence.
TH gene Binding (binding) of
1) Confidence 0.48 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595476 Disease Relevance 0.14 Pain Relevance 0
Using electrophoretic mobility shift assays, we demonstrate that nuclear proteins from rat pheochromocytoma cell lines bind to the region of the TH gene from -102 to -73.
TH gene Binding (bind) of associated with pheochromocytoma
2) Confidence 0.48 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595476 Disease Relevance 0.18 Pain Relevance 0
In all treatment groups chromaffin cells were found which had TH associated with some chromaffin granules.
TH Binding (associated) of in chromaffin cells
3) Confidence 0.41 Published 1981 Journal Brain Res. Section Abstract Doc Link 6112040 Disease Relevance 0.59 Pain Relevance 0.33
This effect is at least partially due to the interaction of transcription factors with the canonical cyclic AMP-response element (CRE) at position -45 to -38 within the TH gene promoter.
TH gene Spec (partially) Binding (interaction) of
4) Confidence 0.37 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595476 Disease Relevance 0.17 Pain Relevance 0
Although immunoreactivity for tyrosine hydroxylase (TH) was almost completely lost in the ipsilateral striatum in hemiparkinsonian rats, TH immunoreactivity was detected in transplanted cells and sprouting fibers.
TH Binding (immunoreactivity) of in striatum
5) Confidence 0.36 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15351793 Disease Relevance 0.07 Pain Relevance 0.31
Although immunoreactivity for tyrosine hydroxylase (TH) was almost completely lost in the ipsilateral striatum in hemiparkinsonian rats, TH immunoreactivity was detected in transplanted cells and sprouting fibers.
tyrosine hydroxylase Binding (immunoreactivity) of in striatum
6) Confidence 0.36 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15351793 Disease Relevance 0.07 Pain Relevance 0.31
Analgesic doses of morphine and viminol R2 increase the turnover rate of dopamine (DA) in rat striatum but fail to increase the striatal concentration of adenosine 3',5'-monophosphate (cAMP) or the affinity of tyrosine hydroxylase (TH) for the pteridine cofactor.
TH Binding (affinity) of in striatum associated with adenocard, dopamine, analgesic and morphine
7) Confidence 0.36 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 239224 Disease Relevance 0 Pain Relevance 0.89
Analgesic doses of morphine and viminol R2 increase the turnover rate of dopamine (DA) in rat striatum but fail to increase the striatal concentration of adenosine 3',5'-monophosphate (cAMP) or the affinity of tyrosine hydroxylase (TH) for the pteridine cofactor.
tyrosine hydroxylase Binding (affinity) of in striatum associated with adenocard, dopamine, analgesic and morphine
8) Confidence 0.36 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 239224 Disease Relevance 0 Pain Relevance 0.89
NADPH-DA colocalized with immunoreactivity to tyrosine hydroxylase (TH), serotonin, vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), methionine-enkephalin and somatostatin.
TH Binding (colocalized) of associated with somatostatin, neuropeptide, enkephalin and serotonin
9) Confidence 0.35 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953706 Disease Relevance 0.56 Pain Relevance 0.31
NADPH-DA colocalized with immunoreactivity to tyrosine hydroxylase (TH), serotonin, vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), methionine-enkephalin and somatostatin.
tyrosine hydroxylase Binding (colocalized) of associated with somatostatin, neuropeptide, enkephalin and serotonin
10) Confidence 0.35 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953706 Disease Relevance 0.56 Pain Relevance 0.31
The remainder formed synapses on dendrites lacking detectable immunoreactivity for TH.
TH Binding (immunoreactivity) of in dendrites
11) Confidence 0.35 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1348271 Disease Relevance 0 Pain Relevance 1.42
The morphological support of interactions between enkephalins and three systems--beta-endorphin (beta-END), tyrosine hydroxylase (TH), or neuropeptide Y (NPY)--well represented in the arcuate nucleus, was examined by using an electron microscopic double immunostaining combining two sensitive chromogens, diaminobenzidine (DAB) and tetramethylbenzidine (TMB).
tyrosine hydroxylase Binding (interactions) of in arcuate nucleus associated with neuropeptide and enkephalin
12) Confidence 0.34 Published 1994 Journal Peptides Section Abstract Doc Link 7984509 Disease Relevance 0 Pain Relevance 0.15
The morphological support of interactions between enkephalins and three systems--beta-endorphin (beta-END), tyrosine hydroxylase (TH), or neuropeptide Y (NPY)--well represented in the arcuate nucleus, was examined by using an electron microscopic double immunostaining combining two sensitive chromogens, diaminobenzidine (DAB) and tetramethylbenzidine (TMB).
TH Binding (interactions) of in arcuate nucleus associated with neuropeptide and enkephalin
13) Confidence 0.34 Published 1994 Journal Peptides Section Abstract Doc Link 7984509 Disease Relevance 0 Pain Relevance 0.15
Similarly to morphine, haloperidol enhances the turnover rate of striatal DA, but unlike morphine it increases the affinity of TH for the pteridine cofactor and blocks the in vitro activation of striatal adenylacte cyclase by DA.
TH Binding (affinity) of associated with dopamine and morphine
14) Confidence 0.32 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 239224 Disease Relevance 0 Pain Relevance 1.01
However (+)-amphetamine (4.8 mumol/kg i.p.) increases DA turnover rate and the striatal cAMP content, but, in doses up to 12.8 mumol/kg i.p., it fails to change the affinity of TH for the pteridine cofactor.
TH Binding (affinity) of associated with dopamine
15) Confidence 0.31 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 239224 Disease Relevance 0 Pain Relevance 0.93
Since anti-TH immunohistochemistry recognizes noradrenergic fibers, the reduction in TH immunoreactivity in the hilus of 6-OHDA treated rats (Fig. 2L) indicates that noradrenergic as well as dopaminergic inputs to the hippocampus have been affected by 6-OHDA treatment in our study.
TH Binding (recognizes) of in hippocampus associated with hippocampus
16) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2822849 Disease Relevance 0.80 Pain Relevance 0.75
The distributions of leu-enkephalin and serotonin immunoreactive cells were similar to each other, but the tyrosine-hydroxylase immunoreactive cells rarely intermingle with the former two immunoreactive cell types.
tyrosine-hydroxylase Binding (intermingle) of associated with enkephalin and serotonin
17) Confidence 0.21 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1679768 Disease Relevance 0 Pain Relevance 1.05
Double labeling with Fos and arginine vasopressin, oxytocin, or tyrosine hydroxylase antibodies was also performed.
tyrosine hydroxylase Binding (labeling) of
18) Confidence 0.16 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7860779 Disease Relevance 0.08 Pain Relevance 0.18
These results indicate that the anti-cholinergic actions of kappa-opioid can be explained partially by its inhibition of both TH enzyme activity and TH synthesis, through suppression of the cAMP/protein kinase A pathway.
TH enzyme Binding (activity) of associated with opioid
19) Confidence 0.15 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 10908734 Disease Relevance 0.21 Pain Relevance 0.80
The rate of catecholamine synthesis, however, appears to be influenced less by precursor levels than is serotonin formation: tyrosine hydroxylase, whcih catalyzes the rate-limiting step in catecholamine synthesis, responds strongly to end-product inhibition and to other controls that reflect variations in neuronal activity.
tyrosine hydroxylase Binding (responds) of in neuronal associated with catecholamine and serotonin
20) Confidence 0.11 Published 1977 Journal Metab. Clin. Exp. Section Abstract Doc Link 13261 Disease Relevance 0.07 Pain Relevance 0.61

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