INT141000

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 9.46
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T24 1
GSK (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 201 100.00 Very High Very High Very High
agonist 16 98.90 Very High Very High Very High
Pyramidal cell 1 87.52 High High
Bile 10 84.88 Quite High
ischemia 8 81.88 Quite High
antagonist 69 80.36 Quite High
COX-2 inhibitor 2 78.64 Quite High
Nerve growth factor 14 74.92 Quite High
Opioid 58 72.64 Quite High
adenocard 20 68.44 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 119 99.44 Very High Very High Very High
Targeted Disruption 155 98.24 Very High Very High Very High
Thyroid Neoplasm 322 98.16 Very High Very High Very High
Infection 93 97.76 Very High Very High Very High
Carcinoma 65 95.28 Very High Very High Very High
Hepatocellular Cancer 5 90.40 High High
Disease 522 90.24 High High
Myeloid Leukemia 70 89.56 High High
Stress 107 87.84 High High
Frailty 15 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H9C2 cells raised in 25 mmol/l compared with 5.56 mmol/l glucose media also demonstrated reduced morphine-induced P-GSK3beta, P-Akt, P-STAT3, and P-ERK1 after 15 min.
Negative_regulation (reduced) of GSK associated with morphine
1) Confidence 0.57 Published 2007 Journal Diabetes Section Abstract Doc Link 17192474 Disease Relevance 0.54 Pain Relevance 0.58
We have shown that treatment with rapamycin impedes the GSK-3?
Negative_regulation (impedes) of GSK
2) Confidence 0.57 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.22 Pain Relevance 0
In contrast, SB216763 is a very specific inhibitor of GSK3?
Negative_regulation (inhibitor) of GSK
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
Although LiCL is a powerful inhibitor of GSK3?
Negative_regulation (inhibitor) of GSK
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
Therefore, LiCl may inhibit GSK3?
Spec (may) Negative_regulation (inhibit) of GSK
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
in the upregulation of Hsp70 by using LiCl, known to be a classical inhibitor of GSK3?
Negative_regulation (inhibitor) of GSK
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
, and it has been suggested that inhibiting GSK-3?
Negative_regulation (inhibiting) of GSK
7) Confidence 0.57 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.27 Pain Relevance 0.05
The M1 muscarinic agonist AF267B (also referred to as NGX267) has been shown to inhibit GSK-3?
Negative_regulation (inhibit) of GSK associated with agonist
8) Confidence 0.57 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.30 Pain Relevance 0.05
Morphine-induced phospho- (P-)GSK3beta was reduced 5 min after reperfusion in DBRs compared with NDBRs (0.83 +/- 0.29 and 1.94 +/- 0.12 [P < 0.05] pg/microg tissue, respectively).
Negative_regulation (reduced) of GSK associated with morphine
9) Confidence 0.57 Published 2007 Journal Diabetes Section Abstract Doc Link 17192474 Disease Relevance 0.55 Pain Relevance 0.59
Inhibition of GSK-3?
Negative_regulation (Inhibition) of GSK
10) Confidence 0.42 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.50 Pain Relevance 0.06
and additional kinases (such as MEK 1/2); and 3) may mediate its antiproliferative effects in T24 cells via inhibition of Akt, GSK3?
Negative_regulation (inhibition) of GSK in T24
11) Confidence 0.42 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.05 Pain Relevance 0
tyr216 phosphorylation without inhibiting GSK3?
Negative_regulation (inhibiting) of GSK
12) Confidence 0.42 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.24 Pain Relevance 0.11
from Axin and leads to the inhibition of GSK-3?.
Negative_regulation (inhibition) of GSK
13) Confidence 0.42 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.30 Pain Relevance 0
For instance, although lithium induces autophagy in an mTOR-independent manner by inhibiting IMPase, it also inhibits GSK-3?
Negative_regulation (inhibits) of GSK
14) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.35 Pain Relevance 0
activity, these data demonstrate that morphine and H37Ra decrease GSK3?
Negative_regulation (decrease) of GSK associated with morphine
15) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.63 Pain Relevance 0.60
As shown in Fig. 3B, morphine and H37Ra significantly decreased the levels of GSK3?
Negative_regulation (decreased) of GSK associated with morphine
16) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.58 Pain Relevance 0.67
ser9 phosphorylation, but a substantial decrease in GSK3?
Negative_regulation (decrease) of GSK
17) Confidence 0.42 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.17 Pain Relevance 0
The phosphorylation based inactivation of GSK3?
Negative_regulation (inactivation) of GSK
18) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
Inactivation of GSK-3?
Negative_regulation (Inactivation) of GSK
19) Confidence 0.42 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.67 Pain Relevance 0
Another study showed that inactivation of GSK-3?
Negative_regulation (inactivation) of GSK
20) Confidence 0.42 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.33 Pain Relevance 0.03

General Comments

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