INT141002

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.17
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 2
paw 1
leaf 1
mast cell 1
Fcer2a (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 82 99.24 Very High Very High Very High
tolerance 18 97.72 Very High Very High Very High
Thermal hyperalgesia 2 94.76 High High
cytokine 114 93.60 High High
Inflammation 220 90.96 High High
amygdala 5 90.36 High High
qutenza 5 88.16 High High
Neurotransmitter 4 84.00 Quite High
Catecholamine 1 82.64 Quite High
chemokine 44 74.80 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 1 100.00 Very High Very High Very High
Anaphylaxis 30 99.84 Very High Very High Very High
Immunization 47 99.28 Very High Very High Very High
Neutrophil Disorders 1 99.00 Very High Very High Very High
Bacterial Respiratory Disease 2 98.22 Very High Very High Very High
Hypersensitivity 230 98.20 Very High Very High Very High
Asthma 168 95.84 Very High Very High Very High
Hyperalgesia 3 94.76 High High
Eczema 119 94.48 High High
Adverse Drug Reaction 1 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BALB/c mice treated with warifteine (0.4-10 mg/Kg) 1 h before OVA sensitization reduced OVA induced paw edema as well as the OVA-specific IgE serum titers as compared with non-treated and OVA-sensitized animals.
Negative_regulation (reduced) of IgE in paw associated with pressure and volume under development
1) Confidence 0.12 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18328442 Disease Relevance 0.70 Pain Relevance 0.09
There was, however, a tendency for total serum IgE to decline by day 27 in mice that were systemically sensitised but not challenged with OVA aerosols, compared to mice additionally exposed to 6 OVA aerosols.
Negative_regulation (decline) of IgE
2) Confidence 0.12 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.08 Pain Relevance 0
This effect has been achieved by generating genetically engineered “hypoallergens” that retain their ability to stimulate T cells but that have reduced IgE antibody binding capacity.
Negative_regulation (reduced) of IgE in T cells
3) Confidence 0.11 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.39 Pain Relevance 0.15
A variety of approaches targeting the suppression of IgE have been proposed such as synthetic peptides and T cell vaccine.
Negative_regulation (suppression) of IgE in T cell
4) Confidence 0.06 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.55 Pain Relevance 0.07
DNA vaccination with the major HDM allergen gene, Der p 1, 2, and 3, and Der f 1, 2, and 3 showed about 50% reduction of HDM-specific IgE and more than 70% reduction of total IgE compared with the control group at 6 weeks after immunization (Fig. 1a and 1b).
Negative_regulation (reduction) of IgE associated with immunization
5) Confidence 0.06 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.28 Pain Relevance 0.09
Removal of IgE by either antibody depletion or the development of oral tolerance precluded all responses analyzed here.
Negative_regulation (Removal) of IgE associated with tolerance
6) Confidence 0.04 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17192560 Disease Relevance 0.76 Pain Relevance 0.40
We showed about 50% reduction of HDM-specific IgE and more than 70% inhibition of total IgE at 6 weeks after immunization compared with control group.
Negative_regulation (reduction) of IgE associated with immunization
7) Confidence 0.04 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.80 Pain Relevance 0.06
DNA vaccination with the major HDM allergen gene, Der p 1, 2, and 3, and Der f 1, 2, and 3 showed about 50% reduction of HDM-specific IgE and more than 70% reduction of total IgE compared with the control group at 6 weeks after immunization (Fig. 1a and 1b).
Negative_regulation (reduction) of IgE associated with immunization
8) Confidence 0.04 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.22 Pain Relevance 0.06
The serum level of IgE, IL-6 and MCP-1 was decreased in PG102-treated mice.
Negative_regulation (decreased) of IgE
9) Confidence 0.04 Published 2009 Journal Int. Arch. Allergy Immunol. Section Body Doc Link 19439982 Disease Relevance 0.42 Pain Relevance 0
We showed about 50% reduction of HDM-specific IgE and more than 70% inhibition of total IgE at 6 weeks after immunization compared with control group.
Negative_regulation (inhibition) of IgE associated with immunization
10) Confidence 0.04 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.80 Pain Relevance 0.07
Administration of vitamin C lowered IgE levels in patients with chronic granulomatous disease (Anderson & Dittrich, 1979) and in patients with bronchial asthma (Anderson et al., 1980).
Negative_regulation (lowered) of IgE associated with asthma and neutrophil disorders
11) Confidence 0.02 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0.27 Pain Relevance 0.08
Indeed, a functionally relevant reduction in IL-4 was suggested by an observed decrease in antigen-specific IgE observed with H4R antagonist treatment.
Negative_regulation (decrease) of IgE associated with antagonist
12) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.20 Pain Relevance 0.35
This last finding may explain the observed significant reduction in serum ova-specific IgE after JNJ 7777120 treatment (see figure S1, additional file 1).


Negative_regulation (reduction) of IgE
13) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.30 Pain Relevance 0.39
Therefore, this FX cream is expected as a useful skin care agent for atopic dry skin colonized by SA.3,4 Recently, we also found that AD-like lesions in DS-Nh of AD model mouse mice were significantly improved together with a decrease in number of SA detected from these lesions by treatment with the bamboo leaf extract cream having the antibacterial, viral and mycotic activity.5 This improvement effect was also observed together with a decrease of the increased serum IgE levels and IFN-?
Negative_regulation (decrease) of IgE in leaf associated with bacterial respiratory disease and eczema
14) Confidence 0.02 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.65 Pain Relevance 0.03
This clearly shows that mast cell expression of CCLR2 is not required for elicitation of IgE-dependent PCA but may substantially enhance reactions elicited under conditions where IgE may be limiting.
Negative_regulation (limiting) of IgE in mast cell associated with anaphylaxis
15) Confidence 0.02 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.75 Pain Relevance 0.04

General Comments

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