INT141015

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.30
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
sympathetic 1
synovium 1
nociceptor 1
microglia 1
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 214 99.96 Very High Very High Very High
rheumatoid arthritis 146 99.84 Very High Very High Very High
depression 22 99.84 Very High Very High Very High
Inflammation 196 99.76 Very High Very High Very High
Arthritis 99 99.04 Very High Very High Very High
tolerance 10 98.68 Very High Very High Very High
antagonist 34 98.16 Very High Very High Very High
Osteoarthritis 5 97.48 Very High Very High Very High
nociceptor 6 96.24 Very High Very High Very High
guanethidine 2 94.68 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 146 99.84 Very High Very High Very High
Depression 22 99.84 Very High Very High Very High
INFLAMMATION 191 99.76 Very High Very High Very High
Arthritis 106 99.04 Very High Very High Very High
Arthropathy 2 98.56 Very High Very High Very High
Parkinson's Disease 12 98.08 Very High Very High Very High
Frailty 5 97.48 Very High Very High Very High
Multiple Organ Failure 2 96.44 Very High Very High Very High
Nociception 1 96.20 Very High Very High Very High
Fungal Infection 5 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the intriguing peculiarities of the central role of IL-18 is that despite the constitutive expression of the receptor, the regulation of IL-18 action appears to be regulated by the existence of truncated isoforms and by the fact that under normal physiological conditions IL-18 is not easily found in the CNS.
Regulation (regulation) of IL-18 associated with central nervous system
1) Confidence 0.59 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.32 Pain Relevance 0.19
The intent of the study contained herein was to determine the effect of IL-18 administration on cardiac function and structure.
Spec (determine) Regulation (effect) of IL-18
2) Confidence 0.45 Published 2008 Journal Perfusion Section Abstract Doc Link 19181757 Disease Relevance 0.29 Pain Relevance 0.18
Interleukin-18: a therapeutic target in rheumatoid arthritis?


Regulation (target) of Interleukin-18 associated with rheumatoid arthritis
3) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1064903 Disease Relevance 0.53 Pain Relevance 0.27
A different member of the IL-1 family, IL-1F7, is also a negative regulator of IL-18 action.
Regulation (regulator) of IL-18
4) Confidence 0.43 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0 Pain Relevance 0.07
IL-18 hypernociception was unaffected in TNFR1(-/-) mice or by the pre-treatment with sIL-15Ralpha (soluble form of IL-15 receptor), BQ788 (ET(B) receptor antagonist) or guanethidine (sympathetic blocker).
Neg (unaffected) Regulation (unaffected) of IL-18 in sympathetic associated with guanethidine and antagonist
5) Confidence 0.43 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17194566 Disease Relevance 0.24 Pain Relevance 0.35
There are evidences that targeting IL-18 might be beneficial to inhibit inflammatory symptoms, including hypernociception (decrease in nociceptive threshold).
Regulation (targeting) of IL-18 associated with nociception and inflammation
6) Confidence 0.27 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18511039 Disease Relevance 0.35 Pain Relevance 0.20
Is IL-18 therefore a good therapeutic target in RA?
Regulation (target) of IL-18 associated with rheumatoid arthritis
7) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.19 Pain Relevance 0.27
After DMARD treatment, there was decreased tissue expression of IL-18 that correlated significantly with change in serum IL-18 and C reactive protein.
Regulation (change) of IL-18
8) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.52 Pain Relevance 0.30
Infectious models in which IL-18 has been targeted or in IL-18 deficient mice clearly show a role for this cytokine in host defence to bacterial and fungal infection [2,29], although IL-18 function has not yet appeared critical.
Regulation (targeted) of IL-18 associated with fungal infection and cytokine
9) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.38 Pain Relevance 0.23
For instance, like other pro-inflammatory cytokines, IL-18 may participate in the control of the activity of the HPA axis reported to be dysregulated in depression [78,144-146].
Regulation (dysregulated) of IL-18 associated with depression, inflammation and cytokine
10) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.16 Pain Relevance 0.38
There is pre-clinical evidence that therapies targeting IL-18 might be beneficial in controlling arthropathies, which are accompanied by hypernociception (nociceptor sensitization).
Regulation (targeting) of IL-18 in nociceptor associated with nociceptor and arthropathy
11) Confidence 0.26 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17194566 Disease Relevance 0.26 Pain Relevance 0.23
Cellular IL-18 responsiveness is determined by the expression of the IL-18 receptor, a heterodimeric complex consisting of IL-18R?
Regulation (responsiveness) of IL-18
12) Confidence 0.18 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.50 Pain Relevance 0.17
IL-18 mRNA and protein has been detected in significantly higher levels in rheumatoid synovium than in osteoarthritis controls [49].
Regulation (detected) of IL-18 in synovium associated with osteoarthritis
13) Confidence 0.11 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 0.70 Pain Relevance 0.30
In KA-induced excitotoxicity, IL-18 immunoreactivity was found in the hippocampal microglia of mice whereas IL-18R immunoreactivity was observed in astrocytes.
Regulation (immunoreactivity) of IL-18 in microglia
14) Confidence 0.11 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 0.60 Pain Relevance 0.29
In addition, IL-6, IL-12 and probably also IL-15 and IL-18 [74,75,76] might prove to be valuable targets in chronic destructive arthritis.
Regulation (targets) of IL-18 associated with arthritis
15) Confidence 0.07 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.28 Pain Relevance 0.29

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