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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.31

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cytoplasm (Crh, Pomc) extracellular space (Crh, Pomc) extracellular region (Crh, Pomc)
cell-cell signaling (Pomc) response to stress (Crh) generation of precursor metabolites and energy (Pomc)
Crh (Rattus norvegicus)
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
local anesthetic 3 96.60 Very High Very High Very High
adenocard 1 95.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRH-induced proopiomelanocortin gene expression plays an important role in stress responses and is affected by a variety of drugs, but it is not known whether local anesthetics can directly affect the gene expression.
CRH Positive_regulation (induced) of Gene_expression (expression) of proopiomelanocortin gene associated with stress and local anesthetic
1) Confidence 0.20 Published 2007 Journal Reg Anesth Pain Med Section Abstract Doc Link 17196494 Disease Relevance 0.10 Pain Relevance 0.31

General Comments

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