INT14103

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.67
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Hrh1) plasma membrane (Hrh1) nucleus (Hrh1)
cytoplasm (Hrh1) signal transducer activity (Hrh1)
Anatomy Link Frequency
neurons 1
skin 1
glands 1
Hrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 13 100.00 Very High Very High Very High
agonist 9 100.00 Very High Very High Very High
qutenza 6 97.66 Very High Very High Very High
Hyperalgesia 4 96.44 Very High Very High Very High
Dorsal horn neuron 2 94.08 High High
carrageenan induced 1 92.20 High High
bradykinin 1 91.68 High High
Inflammation 8 91.40 High High
peripheral neuropathy 1 90.72 High High
Spinal nerve ligature 1 89.60 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 4 99.98 Very High Very High Very High
Rhinitis 1 99.80 Very High Very High Very High
Allergic Dermatitis 1 99.04 Very High Very High Very High
Stress 8 98.56 Very High Very High Very High
Urticaria 1 98.12 Very High Very High Very High
Sprains And Strains 2 97.72 Very High Very High Very High
Hyperalgesia 4 96.44 Very High Very High Very High
Gastric Fistula 1 95.76 Very High Very High Very High
INFLAMMATION 7 91.40 High High
Peripheral Neuropathy 1 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Anti-edema effects of some H1-receptor antagonists].
Regulation (effects) of H1-receptor associated with pressure and volume under development and antagonist
1) Confidence 0.44 Published 1991 Journal Acta Pharm Hung Section Title Doc Link 1686138 Disease Relevance 0.47 Pain Relevance 0.18
The effect of perivagal capsaicin treatment on gastric acid secretion induced by the histamine H2 receptor agonist, dimaprit dihydrochloride, and the effect of the histamine H1 receptor agonist, 2-thiazolylethylamine dihydrochloride, on gastric acid secretion were studied in acute gastric fistula rats anesthetized with urethane.
Regulation (effect) of histamine H1 associated with qutenza, gastric fistula and agonist
2) Confidence 0.42 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2149706 Disease Relevance 0.10 Pain Relevance 0.44
We have investigated the effects of mepyramine, an H1 receptor antagonist, and lysine acetylsalicylate, a cyclo-oxygenase inhibitor, on post-ischaemic hyperalgesia in rats.
Spec (investigated) Regulation (effects) of H1 receptor associated with hyperalgesia and antagonist
3) Confidence 0.39 Published 1986 Journal Pain Section Abstract Doc Link 3774353 Disease Relevance 0.39 Pain Relevance 0.40
We characterized the effect of a novel selective histamine H1 receptor antagonist, (R)-1-(3-(10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5-ylidene)-1-propyl)-3-piperidine carboxylic acid (ReN-1869), on the responses of dorsal horn neurons in anesthetized rats after carrageenan induced-inflammation and peripheral neuropathy (L5/6 spinal nerve ligation; SNL).
Regulation (effect) of H1 receptor in neurons associated with inflammation, spinal nerve ligature, antagonist, peripheral neuropathy, carrageenan induced and dorsal horn neuron
4) Confidence 0.35 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14988422 Disease Relevance 0.33 Pain Relevance 0.47
Effects of H1-receptor antagonists on 14C-aminopyrine accumulated in histamine-stimulated rabbit gastric glands.
Regulation (Effects) of H1-receptor in glands associated with antagonist
5) Confidence 0.17 Published 1993 Journal Scand. J. Gastroenterol. Section Title Doc Link 8094259 Disease Relevance 0 Pain Relevance 0.27
The stimulatory effect of dimaprit, a nonselective histamine H2-receptor agonist on HPA axis was considerably impaired in crowded rats while the response to 2-pyridylethylamine, a H1-receptor agonist was moderately affected.
Regulation (affected) of H1-receptor associated with agonist
6) Confidence 0.06 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10574467 Disease Relevance 0.49 Pain Relevance 0.40
H1 histamine antagonists are effective for hay fever and some skin allergies such as urticaria, which indicates the importance of histamine in these conditions.
Regulation (effective) of H1 histamine in skin associated with urticaria, allergic dermatitis, rhinitis and antagonist
7) Confidence 0.00 Published 1987 Journal FASEB J. Section Abstract Doc Link 3111928 Disease Relevance 0.89 Pain Relevance 0.58

General Comments

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