INT141036

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.26
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aifm1) mitochondrion (Aifm1) oxidoreductase activity (Aifm1)
nucleus (Aifm1) DNA binding (Aifm1) cytoplasm (Aifm1)
Anatomy Link Frequency
spinal nerve 1
Aifm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Brush evoked pain 4 100.00 Very High Very High Very High
dorsal root ganglion 1 100.00 Very High Very High Very High
ectopic activity 1 100.00 Very High Very High Very High
Spontaneous pain 6 95.36 Very High Very High Very High
allodynia 1 94.52 High High
Neuropathic pain 1 94.24 High High
Hyperalgesia 1 94.08 High High
Peripheral nerve injury 1 80.48 Quite High
Lasting pain 1 75.00 Quite High
Hyperpolarization-activated cyclic nucleotide-modulated channel 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 6 100.00 Very High Very High Very High
Ganglion Cysts 1 100.00 Very High Very High Very High
Pain 7 95.36 Very High Very High Very High
Hyperalgesia 2 94.08 High High
Nervous System Injury 1 79.60 Quite High
Injury 5 62.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we documented that systemic administration of ZD7288, a specific blocker of pacemaker current (I(h)), decreased ectopic activity in dorsal root ganglion (DRG) and reversed tactile allodynia in spinal nerve ligated (SNL) rats [Chaplan SR, Guo HQ, Lee DH, Luo L, Liu C, Kuei C, Velumian AA, Butler MP, Brown SM, Dubin AE (2003) Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.
Negative_regulation (decreased) of Guo HQ in spinal nerve associated with ganglion cysts, brush evoked pain, dorsal root ganglion, neuropathic pain and ectopic activity
1) Confidence 0.00 Published 2007 Journal Neuroscience Section Abstract Doc Link 17196750 Disease Relevance 1.26 Pain Relevance 1.07

General Comments

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