INT141037

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.32
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aifm1) mitochondrion (Aifm1) oxidoreductase activity (Aifm1)
nucleus (Aifm1) DNA binding (Aifm1) cytoplasm (Aifm1)
Anatomy Link Frequency
neuronal 1
spinal nerve 1
Aifm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Brush evoked pain 4 99.02 Very High Very High Very High
Neuropathic pain 1 98.96 Very High Very High Very High
Glutamate 144 98.60 Very High Very High Very High
dorsal root ganglion 1 98.28 Very High Very High Very High
ectopic activity 1 97.80 Very High Very High Very High
Spontaneous pain 6 94.40 High High
Peripheral nerve injury 1 89.92 High High
allodynia 1 89.08 High High
Hyperalgesia 1 88.64 High High
Lasting pain 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 109 100.00 Very High Very High Very High
Death 86 99.62 Very High Very High Very High
Neuropathic Pain 6 99.02 Very High Very High Very High
Ganglion Cysts 1 98.28 Very High Very High Very High
Pain 7 93.44 High High
Necrosis 5 89.20 High High
Nervous System Injury 1 89.04 High High
Cancer 2 88.84 High High
Hyperalgesia 2 88.64 High High
Injury 7 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since in HT22 cells, glutamate also induced DNA laddering, mitochondrial proteins such as apoptosis inducing factor (AIF) and endonuclease G (Endo G) released in response to death signals may also play a role in the HT22 neuronal cell line [13].
Positive_regulation (inducing) of AIF in neuronal associated with glutamate, apoptosis and death
1) Confidence 0.45 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.73 Pain Relevance 0.22
To monitor the change in mitochondrial death domain, cytosolic accumulation of pro-caspase-9, cytochrome C and apoptosis inducing factor (AIF) was examined.
Positive_regulation (accumulation) of AIF associated with apoptosis and death
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.20 Pain Relevance 0
Previously, we documented that systemic administration of ZD7288, a specific blocker of pacemaker current (I(h)), decreased ectopic activity in dorsal root ganglion (DRG) and reversed tactile allodynia in spinal nerve ligated (SNL) rats [Chaplan SR, Guo HQ, Lee DH, Luo L, Liu C, Kuei C, Velumian AA, Butler MP, Brown SM, Dubin AE (2003) Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.
Positive_regulation (hyperpolarization-activated) of Guo HQ in spinal nerve associated with ganglion cysts, brush evoked pain, dorsal root ganglion, neuropathic pain and ectopic activity
3) Confidence 0.00 Published 2007 Journal Neuroscience Section Abstract Doc Link 17196750 Disease Relevance 1.38 Pain Relevance 1.16

General Comments

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