INT141038

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.58
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Merkel cells 3
luteal cells 2
corpuscles 1
Hcn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
HCN1 34 100.00 Very High Very High Very High
action potential duration 2 98.44 Very High Very High Very High
Action potential 30 98.40 Very High Very High Very High
Spontaneous pain 12 97.32 Very High Very High Very High
Brush evoked pain 8 95.16 Very High Very High Very High
Thermal hyperalgesia 2 89.24 High High
Peripheral nervous system 2 87.44 High High
Peripheral nerve injury 2 76.68 Quite High
Lasting pain 2 75.00 Quite High
Hyperpolarization-activated cyclic nucleotide-modulated channel 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Injury 10 97.76 Very High Very High Very High
Pain 14 97.32 Very High Very High Very High
Aging 33 95.30 Very High Very High Very High
Neuropathic Pain 12 95.16 Very High Very High Very High
Hyperalgesia 4 89.24 High High
Nervous System Injury 2 76.68 Quite High
Ganglion Cysts 4 62.32 Quite High
Obesity 3 50.00 Quite Low
Heart Rate Under Development 9 5.00 Very Low Very Low Very Low
Hypertrophy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HCN1-3 are expressed in ovarian structures including oocytes, granulosa and thecal cells, and in luteal cells, while HCN 4 is only expressed in the oocytes.
Positive_regulation (expressed) of Gene_expression (expressed) of HCN 4 in luteal cells associated with hcn1
1) Confidence 0.38 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.34 Pain Relevance 0.17
During ageing, as discussed elsewhere [10], there was no significant change in dV/dtmax and APD15, but there was a significant increase (22%) in action potential duration at 75% repolarization in true and latent pacemaker cells.

3.3 Age-dependent increase in pacemaker tissue lacking expression of Nav1.5 and expressing HCN4

Positive_regulation (increase) of Gene_expression (expression) of HCN4 associated with action potential duration and aging
2) Confidence 0.34 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.10 Pain Relevance 0.22
Immunohistochemical staining of plantar skin sections detected HCN1-HCN4 expression in mechanosensory structures (e.g., Meissner's corpuscles and Merkel cells).
Positive_regulation (detected) of Gene_expression (expression) of HCN1-HCN4 in Merkel cells associated with hcn1
3) Confidence 0.17 Published 2007 Journal Neuroscience Section Abstract Doc Link 17196750 Disease Relevance 1.57 Pain Relevance 1.36
Immunohistochemical staining of plantar skin sections detected HCN1-HCN4 expression in mechanosensory structures (e.g., Meissner's corpuscles and Merkel cells).
Positive_regulation (detected) of in corpuscles Gene_expression (expression) of HCN1-HCN4 in Merkel cells associated with hcn1
4) Confidence 0.06 Published 2007 Journal Neuroscience Section Abstract Doc Link 17196750 Disease Relevance 1.57 Pain Relevance 1.36

General Comments

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