INT141052

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.34
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NFATC1) DNA binding (NFATC1) cytoplasm (NFATC1)
Anatomy Link Frequency
nucleus 1
NFAT 1
NFATC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 97 82.16 Quite High
Paracetamol 3 75.00 Quite High
Endocannabinoid 1 69.44 Quite High
metalloproteinase 2 69.24 Quite High
antagonist 42 59.08 Quite High
cINOD 4 57.28 Quite High
imagery 1 29.92 Quite Low
Inflammation 98 5.00 Very Low Very Low Very Low
agonist 24 5.00 Very Low Very Low Very Low
chemokine 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 117 99.48 Very High Very High Very High
Chronic Lymphoid Leukemia 76 82.72 Quite High
Cancer 19 75.36 Quite High
Asthma 315 73.28 Quite High
Fibromyalgia 6 71.96 Quite High
INFLAMMATION 106 56.72 Quite High
Toxicity 9 50.00 Quite Low
Targeted Disruption 20 39.52 Quite Low
Death 6 32.16 Quite Low
Hyperplasia 10 28.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that AM404 inhibited both the binding to DNA and the transcriptional activity of endogenous NFAT and the transcriptional activity driven by the over expressed fusion protein Gal4-NFAT (1-415).
Transcription (activity) of NFAT
1) Confidence 0.44 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17196940 Disease Relevance 0 Pain Relevance 0.24
The NFAT family of transcription factors include the cytoplasmic NFAT transcription factors [NFATc1 (NFATc), NFATc2 (NFATp), NFATc3 (NFAT4, NFATx), NFATc4 (NFAT3), NFATc5] and nuclear NFAT (NFATn).
Transcription (transcription) of NFATc1 in NFAT
2) Confidence 0.32 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.07 Pain Relevance 0.03
At the culture time where control cells differentiate into OCs and show high NFATc1 levels, the RSV analogues at concentrations between 100 nM to 1 ?
Transcription (show) of NFATc1 associated with respiratory syncytial virus
3) Confidence 0.30 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.84 Pain Relevance 0
Calcium dependent activation of calcineurin results in dephosphorylation of cytoplasmic NFAT, leading to NFAT translocation to the nucleus enabling it to activate NFAT regulated gene transcription.
Transcription (transcription) of NFAT in nucleus
4) Confidence 0.13 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.08
In addition, EA did not block NFATc-mediated transcription from a NFAT reporter (Figure 1D).
Transcription (transcription) of NFATc
5) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.42 Pain Relevance 0.14

General Comments

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