INT14106

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Context Info
Confidence 0.51
First Reported 1991
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 7
Disease Relevance 3.85
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Abp1) oxidoreductase activity (Abp1) extracellular region (Abp1)
plasma membrane (Abp1) biological_process (Abp1)
Anatomy Link Frequency
blood 2
bladder 1
Abp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 4 99.44 Very High Very High Very High
Inflammation 123 98.84 Very High Very High Very High
fluoxetine 2 98.00 Very High Very High Very High
cva 1 96.28 Very High Very High Very High
headache 11 88.56 High High
intrathecal 2 85.76 High High
Spinal cord 4 83.76 Quite High
allodynia 6 83.12 Quite High
Antihistamine 1 82.96 Quite High
cerebral cortex 1 81.84 Quite High
Disease Link Frequency Relevance Heat
Nociception 39 99.46 Very High Very High Very High
INFLAMMATION 132 98.84 Very High Very High Very High
Hemorrhage 1 96.28 Very High Very High Very High
Pressure Volume 2 Under Development 1 94.80 High High
Hypertension 4 92.52 High High
Headache Disorders 3 89.20 High High
Neuropathic Pain 6 83.12 Quite High
Dyspepsia 3 80.20 Quite High
Disease 2 79.04 Quite High
Hypotension 2 78.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unilateral chemical stimulation of the VLPA in these rats increased ABP but it remained within normotensive range.
Positive_regulation (increased) of ABP
1) Confidence 0.51 Published 1991 Journal Brain Res. Section Abstract Doc Link 1686212 Disease Relevance 0.25 Pain Relevance 0.12
It was further observed that ith of 8-OH-DAPT (2.5, 5, 10 micrograms/10 microliters), a 5-HT1A receptor agonist, produced a dose-dependent increase of mABP and lowering of HR.
Positive_regulation (increase) of mABP associated with agonist
2) Confidence 0.46 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1796318 Disease Relevance 0.24 Pain Relevance 0.33
Ith administration of fluoxetine (10 micrograms/microliters), one of the presynaptic reuptake inhibitors of 5-HT, produced a marked increase in the mean arterial blood pressure (mABP).
Positive_regulation (increase) of mABP in blood associated with fluoxetine
3) Confidence 0.40 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1796318 Disease Relevance 0.21 Pain Relevance 0.29
It is notable that in the present studies there was an apparent temporal dissociation between local tissue inflammatory changes and the enhancement of reflex responses to bladder stimulation: statistically significant evidence of inflammation occurred prior to (4 and 12 hr) the development of robust and statistically significant enhancement of ABP and EMG responses to UBD which only occurred 24 hr after administration of zymosan.
Positive_regulation (responses) of ABP in bladder associated with inflammation
4) Confidence 0.39 Published 2006 Journal BMC Urol Section Body Doc Link PMC1395324 Disease Relevance 0.75 Pain Relevance 0.32
As supportive treatment, a vitamin B6 (pyridoxal phosphate) substitution appears useful in histamine-intolerant patients as pyridoxal phosphate seems to be crucial for diamine oxidase activity.
Spec (seems) Positive_regulation (crucial) of diamine oxidase
5) Confidence 0.32 Published 1996 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 8645981 Disease Relevance 0.75 Pain Relevance 0.77
Statistically significant increases in ABP and EMG responses to UBD also occurred 24 hr post-zymosan administration but not at earlier timepoints.
Positive_regulation (increases) of ABP
6) Confidence 0.32 Published 2006 Journal BMC Urol Section Body Doc Link PMC1395324 Disease Relevance 0.56 Pain Relevance 0.59
In the studies of inflammation-induced changes in nociception, arterial blood pressure (ABP) and visceromotor responses to graded distension of the urinary bladder were significantly increased relative to controls 24 hr after zymosan administration.


Positive_regulation (increased) of ABP in blood associated with nociception and inflammation
7) Confidence 0.32 Published 2006 Journal BMC Urol Section Abstract Doc Link PMC1395324 Disease Relevance 1.02 Pain Relevance 0.36

General Comments

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