INT141075

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.89
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
hippocampus 2
nerve 1
interneurons 1
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 63 99.56 Very High Very High Very High
Dorsal horn neuron 2 99.40 Very High Very High Very High
Hippocampus 163 99.32 Very High Very High Very High
ketamine 77 95.64 Very High Very High Very High
nMDA receptor 275 92.44 High High
nMDA receptor antagonist 5 86.48 High High
Inflammation 6 84.24 Quite High
Glutamate 50 83.36 Quite High
Dorsal horn 2 83.28 Quite High
cINOD 2 81.40 Quite High
Disease Link Frequency Relevance Heat
Aging 228 99.74 Very High Very High Very High
Neuropathic Pain 6 98.48 Very High Very High Very High
INFLAMMATION 6 84.24 Quite High
Nervous System Injury 5 80.24 Quite High
Congenital Anomalies 6 76.76 Quite High
Cognitive Disorder 59 70.64 Quite High
Hallucination 3 58.32 Quite High
Confusion 1 54.84 Quite High
Sleep Disorders 1 52.56 Quite High
Unconsciousness 14 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Single-cell RT-PCR analysis performed on superficial dorsal horn neurons showed that the incidence of NR2A mRNA-expressing neurons was reduced in nerve-ligated neuropathic mice.
Transcription (expressing) of NR2A in nerve associated with neuropathic pain and dorsal horn neuron
1) Confidence 0.49 Published 2007 Journal Brain Res. Section Abstract Doc Link 17198690 Disease Relevance 0.75 Pain Relevance 0.87
We found that the abundance of NR2A in the PSD fraction from whole hippocampal lysates from Neto1-null mice was reduced by approximately one-third compared with that of wild-type littermates (Figure 9A and 9B).
Transcription (abundance) of NR2A
2) Confidence 0.39 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.08 Pain Relevance 0.04
Growth hormone enhances the mRNA expressions of the GluN1 and GluN2A subunits in the hippocampus (Le Greves et al., 2002).
Transcription (expressions) of GluN2A in hippocampus associated with hippocampus
3) Confidence 0.38 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.53 Pain Relevance 0.54
For example, NR2A and NR2B mRNA are expressed mainly in pyramidal cells, whereas NR2C and NR2D mRNA are present in different subsets of hippocampal interneurons [27]–[30].
Transcription (expressed) of NR2A in interneurons associated with pyramidal cell
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999569 Disease Relevance 0.17 Pain Relevance 0.74
There is little or no effect of aging on the mRNA expression of the GluN2A subunit in the cortex or hippocampus of C57Bl/6 mice (Magnusson, 2000, 2001; Magnusson et al., 2006).
Transcription (expression) of GluN2A subunit in hippocampus associated with aging and hippocampus
5) Confidence 0.25 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.36 Pain Relevance 0.27

General Comments

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