INT14110

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.45
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22)
Anatomy Link Frequency
liver 2
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 215 99.96 Very High Very High Very High
Opioid 1 89.44 High High
Dopamine 1 26.32 Quite Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 6 99.44 Very High Very High Very High
Kidney Cortex Necrosis 2 97.62 Very High Very High Very High
Sepsis 2 97.36 Very High Very High Very High
Stress 2 81.44 Quite High
Death 46 78.08 Quite High
Toxicity 21 75.00 Quite High
Nephrotoxicity 10 75.00 Quite High
Sprains And Strains 4 65.92 Quite High
Overdose 9 63.32 Quite High
Liver Failure 1 62.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, all three methyl groups appear to be required for P-450 activation by methylxanthines.
Positive_regulation (required) of Positive_regulation (activation) of P-450
1) Confidence 0.67 Published 1991 Journal Drug Metab. Dispos. Section Abstract Doc Link 1686244 Disease Relevance 0 Pain Relevance 0.40
Renal cortical necrosis induced by acetaminophen (APAP) may be related to generation of reactive intermediates by two mechanisms of metabolic activation, direct P-450 dependent metabolic activation (P-450) or metabolic activation subsequent to deacetylation of APAP to p-aminophenol (PAP).
Positive_regulation (activation) of Positive_regulation (activation) of P-450 associated with paracetamol and kidney cortex necrosis
2) Confidence 0.15 Published 1985 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 4035671 Disease Relevance 0.37 Pain Relevance 0.64
Renal cortical necrosis induced by acetaminophen (APAP) may be related to generation of reactive intermediates by two mechanisms of metabolic activation, direct P-450 dependent metabolic activation (P-450) or metabolic activation subsequent to deacetylation of APAP to p-aminophenol (PAP).
Positive_regulation (activation) of Positive_regulation (activation) of P-450 associated with paracetamol and kidney cortex necrosis
3) Confidence 0.15 Published 1985 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 4035671 Disease Relevance 0.37 Pain Relevance 0.69
In contrast to induction by phenobarbital, induction of cytochrome P-450 by 3-methylcholanthrene enhanced the microsomal oxidation of PAR and its derivatives.
Positive_regulation (enhanced) of Positive_regulation (induction) of P-450 associated with paracetamol
4) Confidence 0.09 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3778500 Disease Relevance 0.16 Pain Relevance 0.81
Nitric oxide mediates hepatic cytochrome P450 dysfunction induced by endotoxin.
Positive_regulation (mediates) of Positive_regulation (induced) of P450
5) Confidence 0.05 Published 1996 Journal Anesthesiology Section Title Doc Link 8669685 Disease Relevance 0.10 Pain Relevance 0.09
It has long been known from the work of the Brodie group [38], [39] that induction of P-450 enhances AAP-mediated liver toxicity [36].
Positive_regulation (enhances) of Positive_regulation (induction) of P-450 in liver associated with paracetamol and hepatotoxicity
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.45 Pain Relevance 0.83

General Comments

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