INT14111

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 41
Total Number 45
Disease Relevance 7.24
Pain Relevance 17.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22)
Anatomy Link Frequency
liver 6
hepatocytes 3
brain 2
kidney 2
molar 1
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 510 100.00 Very High Very High Very High
Potency 8 99.92 Very High Very High Very High
lidocaine 28 99.52 Very High Very High Very High
dexamethasone 9 99.50 Very High Very High Very High
Morphine 12 99.32 Very High Very High Very High
Taxol 6 99.10 Very High Very High Very High
Opioid 1 89.44 High High
isoflurane 6 87.64 High High
anesthesia 3 86.00 High High
Bile 2 84.08 Quite High
Disease Link Frequency Relevance Heat
Cirrhosis 9 99.92 Very High Very High Very High
Hepatotoxicity 23 99.50 Very High Very High Very High
Nephrotoxicity 19 98.98 Very High Very High Very High
Sprains And Strains 16 98.84 Very High Very High Very High
Injury 9 98.74 Very High Very High Very High
Cancer 5 98.42 Very High Very High Very High
Toxicity 50 98.20 Very High Very High Very High
Acute Renal Failure 2 98.12 Very High Very High Very High
Sepsis 2 97.36 Very High Very High Very High
Kidney Cortex Necrosis 2 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to caffeine, none of the mono- and dimethylxanthines (2.5 mM) activated P-450.
Positive_regulation (activated) of P-450
1) Confidence 0.67 Published 1991 Journal Drug Metab. Dispos. Section Abstract Doc Link 1686244 Disease Relevance 0 Pain Relevance 0.39
Acetone yielded a pattern of P450 activation very different from that of either caffeine or flavone; the maximal degree of activation (3 times control) was observed in microsomes prepared from adult females.
Positive_regulation (activation) of P450
2) Confidence 0.67 Published 1991 Journal Drug Metab. Dispos. Section Abstract Doc Link 1686244 Disease Relevance 0 Pain Relevance 0.22
Thus, all three methyl groups appear to be required for P-450 activation by methylxanthines.
Positive_regulation (activation) of P-450
3) Confidence 0.67 Published 1991 Journal Drug Metab. Dispos. Section Abstract Doc Link 1686244 Disease Relevance 0 Pain Relevance 0.40
Pair feeding also significantly altered drug disposition with an increase in the molar ratio of urinary APAP-mercapturic acid conjugate, but not the absolute amount, suggesting possible increased cytochrome P-450 dependent drug metabolizing enzyme activity.
Spec (possible) Positive_regulation (increased) of P-450 in molar associated with paracetamol
4) Confidence 0.61 Published 1987 Journal Drug Nutr Interact Section Abstract Doc Link 3569050 Disease Relevance 0.28 Pain Relevance 0.67
Based on these results, we conclude that lidocaine deethylase activity of P-450 is increased by these five barbiturates whether levels of P-450 are increased quantitatively, or not.
Neg (not) Spec (whether) Positive_regulation (increased) of P-450 associated with lidocaine
5) Confidence 0.47 Published 1994 Journal Masui Section Abstract Doc Link 7815706 Disease Relevance 0 Pain Relevance 0.41
The potency of P-450 induction was in descending order of PB, TI, AB, HB and PT.
Positive_regulation (induction) of P-450 associated with potency
6) Confidence 0.47 Published 1994 Journal Masui Section Abstract Doc Link 7815706 Disease Relevance 0 Pain Relevance 0.40
Based on these results, we conclude that lidocaine deethylase activity of P-450 is increased by these five barbiturates whether levels of P-450 are increased quantitatively, or not.
Spec (whether) Positive_regulation (increased) of P-450 associated with lidocaine
7) Confidence 0.47 Published 1994 Journal Masui Section Abstract Doc Link 7815706 Disease Relevance 0 Pain Relevance 0.40
Also we found the positive linear relationship between the potency of P-450 induction and the elimination half time (t1/2 beta) of the barbiturates.
Positive_regulation (induction) of P-450 associated with potency
8) Confidence 0.41 Published 1994 Journal Masui Section Abstract Doc Link 7815706 Disease Relevance 0 Pain Relevance 0.42
Concentrations of cytochromes b5 and p-450 and specific activities of microsomal defluorinase and several cytosolic enzymes were significantly lower in cirrhotic than in noncirrhotic liver, but their total amounts in whole liver were the same.
Positive_regulation (Concentrations) of p-450 in liver associated with cirrhosis
9) Confidence 0.40 Published 1989 Journal Anesth. Analg. Section Abstract Doc Link 2919755 Disease Relevance 0.90 Pain Relevance 0.32
A 30% decrease in cytochromes P-450 induced by cobalt chloride failed to provide protection against APAP lethality.
Positive_regulation (induced) of cytochromes P-450 associated with paracetamol
10) Confidence 0.34 Published 1995 Journal Hepatology Section Abstract Doc Link 7843722 Disease Relevance 0.36 Pain Relevance 1.06
Administration of testosterone elevated the levels of total P-450, aminopyrine N-demethylase and morphine N-demethylase in female rat brain to levels comparable with that of the male rat brain.
Positive_regulation (elevated) of P-450 in brain associated with morphine
11) Confidence 0.30 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1881602 Disease Relevance 0 Pain Relevance 0.19
The increase in the Cl(f) of NAPQI immediately after a single dose of caffeine demonstrates that P450 activation by caffeine can occur in vivo, as we observed previously in microsomes.
Positive_regulation (activation) of P450
12) Confidence 0.28 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8613932 Disease Relevance 0 Pain Relevance 0.47
Daily injection of promethazine over 4 days significantly increased the liver cytochrome P-450 content and ethyl morphine N-demethylase activity.
Positive_regulation (increased) of P-450 in liver associated with morphine
13) Confidence 0.28 Published 1981 Journal Br J Exp Pathol Section Abstract Doc Link 7295538 Disease Relevance 0 Pain Relevance 0.10
Total cytochromes P-450 of liver and kidney of rats were decreased to 25-30% of control values after 20 h fasting and 4 min of ether anaesthesia, but were restored to normal levels 2 h later.
Positive_regulation (restored) of cytochromes P-450 in kidney
14) Confidence 0.25 Published 1991 Journal Xenobiotica Section Abstract Doc Link 2058176 Disease Relevance 0.07 Pain Relevance 0
Thiopental increased cellular oxygen consumption rate (VO2) in both +PB and -PB cells significantly, as did aminopyrine, a test substrate for PB-inducible cytochrome P450 activity.
Positive_regulation (inducible) of P450
15) Confidence 0.24 Published 1988 Journal Anesth. Analg. Section Abstract Doc Link 3421495 Disease Relevance 0.14 Pain Relevance 0.25
Our findings suggest that the enhancement of P-450 and EM-ase activity result from the decelerating effect of promethazine on protein degradation.
Positive_regulation (enhancement) of P-450
16) Confidence 0.23 Published 1981 Journal Br J Exp Pathol Section Abstract Doc Link 7295538 Disease Relevance 0 Pain Relevance 0.08
Such strain differences have been attributed to differences in renal P-450 activation of APAP or the deacetylation of APAP to the nephrotoxic metabolite, p-aminophenol (PAP).
Positive_regulation (activation) of P-450 associated with paracetamol and sprains and strains
17) Confidence 0.22 Published 1983 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6868091 Disease Relevance 0.50 Pain Relevance 0.78
Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver.
Positive_regulation (induction) of cytochromes P-450 in liver
18) Confidence 0.22 Published 1988 Journal Biochem. Pharmacol. Section Title Doc Link 2840913 Disease Relevance 0.08 Pain Relevance 0
Administration of 3-methylcholanthrene, selectively induced the levels of ethoxycoumarin O-deethylase (ECD) and arylhydrocarbon hydroxylase, although the levels of total P-450 were not increased. 3-Methylcholanthrene induction was also accompanied by a shift in the absorption maximum of the reduced carbon monoxide difference spectrum from 452 to 448 nm.
Neg (not) Positive_regulation (increased) of P-450
19) Confidence 0.21 Published 1990 Journal Brain Res. Section Abstract Doc Link 2085761 Disease Relevance 0 Pain Relevance 0.23
Prior treatment with phenobarbital resulted in two-fold increase of total P-450 and selective induction of aminopyrine N-demethylase (APD) and morphine N-demethylase (MND) activities.
Positive_regulation (increase) of P-450 associated with morphine
20) Confidence 0.21 Published 1990 Journal Brain Res. Section Abstract Doc Link 2085761 Disease Relevance 0 Pain Relevance 0.10

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