INT141116

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.10
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn2a1)
Anatomy Link Frequency
neurons 2
neuronal 1
liver 1
muscle 1
SCN 1
Scn2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 290 98.40 Very High Very High Very High
tetrodotoxin 6 97.88 Very High Very High Very High
Action potential 35 97.20 Very High Very High Very High
Intracerebroventricular 9 89.88 High High
tolerance 3 80.08 Quite High
imagery 13 73.68 Quite High
antagonist 24 73.08 Quite High
Glutamate 67 69.04 Quite High
agonist 28 68.16 Quite High
substance P 33 66.92 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 128 84.16 Quite High
Cancer 59 80.68 Quite High
Targeted Disruption 40 68.08 Quite High
Lymphatic System Cancer 3 67.88 Quite High
Aging 10 65.48 Quite High
Ganglion Cysts 12 52.20 Quite High
Congenital Anomalies 3 47.60 Quite Low
Disease 41 42.80 Quite Low
Breast Cancer 68 38.80 Quite Low
Affective Disorder 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The circadian peak of VP gene transcription in the SCN in vitro is completely blocked by a 2 h exposure to tetrodotoxin (TTX) in the culture medium, and this TTX inhibition of VP gene transcription is reversed by exposure of the SCN to either forskolin or potassium depolarization.
Transcription (transcription) of SCN in SCN associated with tetrodotoxin
1) Confidence 0.45 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17202481 Disease Relevance 0 Pain Relevance 0.36
It is also reported that at the level of the SCN the direct excitatory effects of histamine on neuronal firing is mediated via H1 receptors and the inhibitory effects via H2 receptors [82,83].
Transcription (level) of SCN in neuronal
2) Confidence 0.43 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.05 Pain Relevance 0.40
Arima and co-workers [188] reported AVP transcription in the SCN in long-term organotypic cultures.
Transcription (transcription) of SCN
3) Confidence 0.43 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.04
Using real-time analysis of gene expression, Yamaguchi and co-workers [30] have shown synchronized rhythms of clock gene transcription across hundreds of neurons within the mammalian SCN.
Transcription (transcription) of SCN in neurons
4) Confidence 0.43 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.39 Pain Relevance 0.18
One immediate question following these observations would be if the Ca2+ spiking activity of SCN neurons can exhibit any circadian variation similar to the circadian AP firing activity, and here we studied that issue.
Transcription (activity) of SCN in neurons associated with action potential
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.13
It is known that in mice experiencing a phase advance, Per1 mRNA rhythms in the SCN rapidly readjust to the new light:dark cycle but the peripheral organs (liver, lung, muscle) take nearly 6 times as long as the SCN to recover [77].
Transcription (rhythms) of SCN in muscle
6) Confidence 0.05 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.14 Pain Relevance 0
The peak expression of Bmal1 in the rat ovary is about 4 hours delayed relative to the acrophase of Bmal1 mRNA in the SCN.
Transcription (acrophase) of SCN in ovary
7) Confidence 0.05 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.24 Pain Relevance 0
It is known that in mice experiencing a phase advance, Per1 mRNA rhythms in the SCN rapidly readjust to the new light:dark cycle but the peripheral organs (liver, lung, muscle) take nearly 6 times as long as the SCN to recover [77].
Transcription (rhythms) of SCN in lung
8) Confidence 0.02 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.14 Pain Relevance 0
It is known that in mice experiencing a phase advance, Per1 mRNA rhythms in the SCN rapidly readjust to the new light:dark cycle but the peripheral organs (liver, lung, muscle) take nearly 6 times as long as the SCN to recover [77].
Transcription (rhythms) of SCN in liver
9) Confidence 0.02 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.14 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox