INT141125

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 13
Disease Relevance 8.81
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (GAD1) plasma membrane (GAD1) intracellular (GAD1)
Anatomy Link Frequency
epithelium 6
neurons 4
putamen 2
interneurons 2
GAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 6 100.00 Very High Very High Very High
GABAergic 458 99.66 Very High Very High Very High
Dopamine 2 99.36 Very High Very High Very High
Nicotine 81 97.68 Very High Very High Very High
gABA 535 96.48 Very High Very High Very High
GABA receptor 9 96.24 Very High Very High Very High
Glutamate 45 95.60 Very High Very High Very High
Neuropeptide 6 93.68 High High
Dynorphin 2 92.64 High High
antagonist 38 54.64 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 123 100.00 Very High Very High Very High
Nicotine Addiction 612 99.98 Very High Very High Very High
Stress 22 99.84 Very High Very High Very High
Parkinson's Disease 2 99.76 Very High Very High Very High
Disease 14 97.72 Very High Very High Very High
Adenocarcinoma 9 96.20 Very High Very High Very High
Aging 4 91.52 High High
Asthma 36 87.92 High High
Hyperplasia 18 77.56 Quite High
Death 9 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucocorticoid hormones can modulate GAD expression by transcriptional activation of the GAD67 promoter [38].
Regulation (modulate) of Gene_expression (expression) of GAD associated with generalized anxiety disorder
1) Confidence 0.52 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.82 Pain Relevance 0.38
It is known that nicotine, by activating nicotinic acetylcholine receptors located on cortical or hippocampal GABAergic interneurons, can up-regulate GAD67 expression via an epigenetic mechanism [32].
Regulation (regulate) of Gene_expression (expression) of GAD67 in interneurons associated with gabaergic and nicotine
2) Confidence 0.52 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.79 Pain Relevance 0.31
The mechanisms responsible for GAD67 gene expression up-regulation by cigarette smoking remain to be elucidated.
Regulation (responsible) of Gene_expression (expression) of GAD67 gene associated with nicotine addiction
3) Confidence 0.52 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.68 Pain Relevance 0.36
Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.
Regulation (Alterations) of Gene_expression (levels) of GAD67 in putamen associated with enkephalin and disease
4) Confidence 0.39 Published 2007 Journal J. Neurosci. Res. Section Title Doc Link 17203488 Disease Relevance 0.56 Pain Relevance 0.39
These findings contrast with animal models of parkinsonism, for which expression of pDYN, pENK, and GAD67 mRNA has been reported to change after striatal dopamine denervation.
Regulation (change) of Gene_expression (expression) of GAD67 associated with parkinson's disease and dopamine
5) Confidence 0.39 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17203488 Disease Relevance 0.76 Pain Relevance 0.21
The mechanisms responsible for GAD67 gene expression up-regulation by cigarette smoking remain to be elucidated.
Regulation (regulation) of Gene_expression (expression) of GAD67 gene associated with nicotine addiction
6) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.68 Pain Relevance 0.36
Interestingly, when human airway epithelial cell line 16HBE was treated with cigarette smoking extract in vitro, GAD67 gene expression was also up-regulated (not shown).


Regulation (regulated) of Gene_expression (expression) of GAD67 gene in epithelial cell associated with nicotine addiction
7) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.69 Pain Relevance 0.03
Interestingly, of the entire GABAergic system, smoking modified only the expression of GAD67, with marked up-regulation of GAD67 gene expression in both large (4.1-fold increase, p < 0.01) and small airway epithelium of healthy smokers (6.3-fold increase, p < 0.01).
Regulation (modified) of Gene_expression (expression) of GAD67 in epithelium associated with nicotine addiction and gabaergic
8) Confidence 0.23 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2988726 Disease Relevance 0.61 Pain Relevance 0.49
Interestingly, nuclear factor-kappa B activation through oxidative stress can up-regulate GAD67 expression [36], and the early growth response factor 1-related pathway also mediates GAD67 up-regulation [37].
Regulation (regulate) of Gene_expression (expression) of GAD67 associated with stress
9) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.86 Pain Relevance 0.30
Interestingly, the expression of GAD67 was markedly modified by smoking, with increased expression in healthy smokers compared to healthy nonsmokers at the mRNA and protein levels.
Regulation (modified) of Gene_expression (expression) of GAD67 associated with nicotine addiction
10) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.95 Pain Relevance 0.32
Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium

Background

Regulation (regulation) of Gene_expression (expression) of GAD67 in epithelium associated with nicotine addiction
11) Confidence 0.23 Published 2010 Journal Respir Res Section Title Doc Link PMC2988726 Disease Relevance 0.39 Pain Relevance 0.49
For the MCH/GAD study, MCH and MCH/GAD neurons were plotted on sections taken every 300 µm (7 sections/rat, between AP ?
Regulation (plotted) of Gene_expression (neurons) of GAD in neurons associated with generalized anxiety disorder
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909908 Disease Relevance 0.51 Pain Relevance 0
For the MCH/GAD study, MCH and MCH/GAD neurons were plotted on sections taken every 300 µm (7 sections/rat, between AP ?
Regulation (plotted) of Gene_expression (study) of GAD in neurons associated with generalized anxiety disorder
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909908 Disease Relevance 0.51 Pain Relevance 0

General Comments

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